Structure, Activation, and Biology of Calpain-Reference-Cited by-同舟云学术

Structure, Activation, and Biology of Calpain

Published:2004-02-01 Issue:suppl_1 Volume:53 Page:S12-S18
ISSN:0012-1797
Container-title:Diabetes
language:en
Short-container-title:

Author:

Suzuki Koichi¹,Hata Shoji²,Kawabata Yukiko²,Sorimachi Hiroyuki²

Affiliation:

1. Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan

2. Laboratory of Biological Function, Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, the University of Tokyo, Tokyo, Japan

Abstract

Variation in the calpain 10 gene has recently been shown to be associated with type 2 diabetes by positional cloning. Since then, studies on calpain 10 have been started in correlation with diabetes and insulin-mediated signaling. In this review, the activation mechanism of calpain by calcium ions, which is essential to understand its physiological functions, is discussed on the basis of recent X-ray structural analyses. Further, special features of the structure of calpain 10 that differ from those of typical μ- or m-calpain used in most studies are summarized together with discussion of the physiological function of calpain with respect to type 2 diabetes.

Publisher

American Diabetes Association

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

https://journals.org/diabetes/diabetes/article-pdf/53/suppl_1/S12/377552/zdb10204000s12.pdf

Reference44 articles.

1. Saido TC, Sorimachi H, Suzuki K: Calpain: new perspectives in molecular diversity and physiological, pathological involvement. FASEB J 8:814–822,1994

2. Sorimachi H, Ishiura S, Suzuki K: Structure and physiological function of calpains. Biochem J 328:721–732,1997

3. Carafoli E, Molinari M: Calpain: a protease in search of a function?Biochem Biophys Res Commun 247:193–203,1998

4. Sorimachi H, Suzuki K: The structure of calpain. J Biochem 129:653–664,2001

5. Huang Y, Wang KKW: The calpain family and human disease. Trend Mol Med 7:355–362,2001

Cited by 349 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Exploring Intrinsic Disorder in Human Synucleins and Associated Proteins;International Journal of Molecular Sciences;2024-08-01

2. The endothelium: gatekeeper to lung ischemia-reperfusion injury;Respiratory Research;2024-04-18

3. A Systematic Investigation of Proteoforms with N‐Terminal Glycine and Their Dynamics Reveals Its Impacts on Protein Stability;Angewandte Chemie International Edition;2024-01-08

4. A Systematic Investigation of Proteoforms with N‐Terminal Glycine and Their Dynamics Reveals Its Impacts on Protein Stability;Angewandte Chemie;2024-01-08

5. Genetic polymorphisms of calpain1 and calpain3 genes and their effects on growth, carcass, and meat quality traits in Betong chicken (KU line);Animal Science Journal;2024-01