Prospective Study of the Association Between the Proline to Alanine Codon 12 Polymorphism in the PPARγ Gene and Type 2 Diabetes-Reference-Cited by-同舟云学术

Prospective Study of the Association Between the Proline to Alanine Codon 12 Polymorphism in the PPARγ Gene and Type 2 Diabetes

Published:2003-10-01 Issue:10 Volume:26 Page:2915-2917
ISSN:0149-5992
Container-title:Diabetes Care
language:en
Short-container-title:

Author:

Memisoglu Asli¹,Hu Frank B.²,Hankinson Susan E.¹³,Liu Simin⁴,Meigs James B.⁵,Altshuler David M.⁶,Hunter David J.¹³⁷,Manson JoAnn E.¹³⁴

Affiliation:

1. Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts

2. Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts

3. Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women’s Hospital, Boston, Massachusetts

4. Division of Preventive Medicine, Department of Medicine, Harvard Medical School and Brigham and Women’s Hospital, Boston, Massachusetts

5. General Medicine Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts

6. Department of Genetics, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts

7. Harvard School of Public Health, Center for Cancer Prevention, Boston, Massachusetts

Abstract

OBJECTIVE—To determine whether the Pro12Ala polymorphism in the PPARγ gene was associated with risk of type 2 diabetes in the Nurses’ Health Study. RESEARCH DESIGN AND METHODS—The study was a nested case-control study of 387 incident cases of type 2 diabetes and 771 matching control subjects nested within the Nurses’ Health Study, a prospective cohort study. Association between PPARγ genotype and incident type 2 diabetes was estimated using logistic regression. RESULTS—Carriers of the PPARγ variant 12Ala allele had reduced risk of type 2 diabetes compared with noncarriers. Unadjusted and adjusted odds ratios of type 2 diabetes were 0.74 (95% CI 0.55–1.00) and 0.72 (0.52–0.99), respectively. CONCLUSIONS—The results of this study provide further support for an inverse association between the PPARγ variant 12Ala allele and risk of type 2 diabetes.

Publisher

American Diabetes Association

Subject

Advanced and Specialized Nursing,Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

https://diabetesjournals.org/care/article-pdf/26/10/2915/590161/dc1003002915.pdf

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