Affiliation:
1. Division of Endocrinology, Diabetes, and Medical Genetics, Medical University of South Carolina, Charleston, South Carolina
2. Department of Biometry, Medical University of South Carolina, Charleston, South Carolina
3. Department of Biochemistry, North Carolina State University, Raleigh, North Carolina
4. Ralph H. Johnson Veterans Affairs Medical Center, Charleston, South Carolina
Abstract
OBJECTIVE—To relate the nuclear magnetic resonance (NMR)-determined lipoprotein profile, conventional lipid and apolipoprotein measures, and in vitro oxidizibility of LDL with gender and glycemia in type 1 diabetes.
RESEARCH DESIGN AND METHODS—In the 1997–1999 Diabetes Control and Complications Trial/Epidemiology of Diabetes Intervention and Complications (DCCT/EDIC) cohort, serum from 428 women and 540 men were characterized by conventional lipids, NMR, apolipoprotein levels, and LDL susceptibility to in vitro oxidation. Simple and partial correlation coefficients were calculated for each lipoprotein-related parameter versus gender, with and without covariates (age, diabetes duration, concurrent HbA1c, DCCT randomization, hypertension, BMI, waist-to-hip ratio, and albuminuria). For concurrent HbA1c, data were analyzed as above, exchanging gender for HbA1c. Associations were significant if P < 0.05.
RESULTS—Although men and women had similar total and LDL cholesterol and triglycerides, men exhibited the following significant percent differences in NMR profiles versus women: small VLDL 41; IDL −30; medium LDL 39; small LDL 21; large HDL −32; small HDL 35; LDL particle concentration 4; VLDL and HDL diameters −8 and −4, respectively. Small VLDL, small HDL, medium LDL (women only), small LDL (men only), and LDL particle concentration were positively correlated, and HDL size was inversely correlated, with concurrent HbA1c. NMR profile was unrelated to prior DCCT randomization. Susceptibility of LDL to oxidation was unrelated to gender and glycemia.
CONCLUSIONS—Male gender and poor glycemia are associated with a potentially more atherogenic NMR lipoprotein profile. Neither gender nor glycemia influence LDL oxidation in vitro.
Publisher
American Diabetes Association
Subject
Advanced and Specialized Nursing,Endocrinology, Diabetes and Metabolism,Internal Medicine
Reference49 articles.
1. Herman WH, Crofford OB: Diabetic Control and Complications. In Chronic Complication of Diabetes. Pickup JC, Williams G, Eds. Melbourne, Blackwell Press, 1994, p. 41.1–41.11
2. Pyorala K: Diabetes and heart disease. In Prevention and Treatment of the Diabetic Late Complications. Mogensen CE, Standl E, Eds. New York, Walter de Gruyter, 1989, p.151–168
3. Taskinen MR: Hyperlipidaemia in diabetes. In Lipid and Lipoprotein Disorders Bailliere’s Clinical Endocrinology and Metabolism. Betteridge DJ, Ed. London, 1990, p.743–775
4. Tomkin GH, Owens D: Insulin and lipoprotein metabolism with special reference to the diabetic state. Diabete Metab Rev 10: 225–252, 1994
5. Lyons TJ, Klein RL, Baynes JW, Stevenson HC, Lopes-Virella MF: Stimulation of cholesteryl ester synthesis in human monocyte-derived macrophages by lipoproteins from type I diabetic subjects: the influence of non-enzymatic glycosylation of low-density lipoproteins. Diabetologia 30:916–923, 1987
Cited by
96 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献