2021年度中国神经外科领域高价值论文TOP100
以往我们对一篇论文的价值评估,是通过期刊影响因子或被引频次来判断,这种采用单一指标评判论文的学术价值因有失偏颇而广受诟病。北京同舟云网络信息技术有限公司创立了一种优选算法,综合考虑Metrics 期刊评分、论文被引频次、文献类型以及论文发表时间等多种因素,对每篇论文进行深度解析与计算,并赋予分值,以量化每篇论文的学术价值和影响力。本推荐表是在系统全面准确地统计中国机构作者发表的神经外科国际论文的基础上(说明:神经外科领域专家为主要完成人发表的全部论文均入选,不再筛选论文的内容主题),对每篇论文依上述方法进行计算并赋分排名而得出的,供相关学者学习、评判、参考和借鉴。
序号 | 年份 | 标题 | 期刊 | 主要完成人 | 论文评分 | 1 | 2021 | Circular RNA-encoded oncogenic E-cadherin variant promotes glioblastoma tumorigenicity through activation of EGFR-STAT3 signalling | NAT CELL BIOL | 张弩,中山大学,附属第一医院,神经外科; | 5175.04 | 2 | 2021 | Biomimicking Antibacterial Opto-Electro Sensing Sutures Made of Regenerated Silk Proteins | ADV MATER | 陈亮,复旦大学上海医学院,华山医院,神经外科; | 5023.68 | 3 | 2021 | Highly Permeable DNA Supramolecular Hydrogel Promotes Neurogenesis and Functional Recovery after Completely Transected Spinal Cord Injury | ADV MATER | 桂松柏,首都医科大学,附属北京天坛医院/第五临床医学院,神经外科; | 4767.68 | 4 | 2021 | m6A regulator-mediated methylation modification patterns and characteristics of immunity and stemness in low-grade glioma | BRIEF BIOINFORM | 胡韶山,哈尔滨医科大学,附属第二医院,神经外科; | 4283.2 | 5 | 2021 | Machine learning revealed stemness features and a novel stemness-based classification with appealing implications in discriminating the prognosis, immunotherapy and temozolomide responses of 906 glioblastoma patients | BRIEF BIOINFORM | 马文斌,中国医学科学院,北京协和医院,神经外科; | 4027.2 | 6 | 2021 | An Upstream Open Reading Frame in Phosphatase and Tensin Homolog Encodes a Circuit Breaker of Lactate Metabolism | CELL METAB | 张弩,中山大学,附属第一医院,神经外科; | 3906.4 | 7 | 2021 | A novel somatosensory spatial navigation system outside the hippocampal formation | CELL RES | 张生家,陆军军医大学,新桥医院,神经外科; | 3793.12 | 8 | 2021 | Clinical practice guidelines for the management of adult diffuse gliomas | CANCER LETT | 杨学军,天津医科大学,总医院,神经外科; | 3737.6 | 9 | 2021 | Cathepsin B-responsive and gadolinium-labeled branched glycopolymer-PTX conjugate-derived nanotheranostics for cancer treatment | ACTA PHARMACOL SIN B | 刘艳辉,四川大学,华西医院,神经外科; | 3567.52 | 10 | 2021 | A novel protein encoded by circular SMO RNA is essential for Hedgehog signaling activation and glioblastoma tumorigenicity | GENOME BIOL | 张弩,中山大学,附属第一医院,神经外科; | 3396.48 | 11 | 2021 | An electric-field-responsive paramagnetic contrast agent enhances the visualization of epileptic foci in mouse models of drug-resistant epilepsy | NAT BIOMED ENG | 毛颖,复旦大学上海医学院,华山医院,神经外科; | 3288.32 | 12 | 2021 | A distinct D1-MSN subpopulation down-regulates dopamine to promote negative emotional state | CELL RES | 马兰,复旦大学上海医学院,神经外科,; | 3281.12 | 13 | 2021 | Structural basis of ALMT1-mediated aluminum resistance in Arabidopsis | CELL RES | 杨巍,浙江大学,基础医学院,神经外科; | 3281.12 | 14 | 2021 | Sequential fate-switches in stem-like cells drive the tumorigenic trajectory from human neural stem cells to malignant glioma | CELL RES | 汪源,四川大学,华西基础医学院与法医学院,神经外科; | 3281.12 | 15 | 2021 | Neutrophil-like Cell-Membrane-Coated Nanozyme Therapy for Ischemic Brain Damage and Long-Term Neurological Functional Recovery | ACS NANO | 王燕,上海交通大学医学院,第六人民医院,神经外科; | 3230.08 | 16 | 2021 | Tumor Acidity and Near-Infrared Light Responsive Dual Drug Delivery Polydopamine-Based Nanoparticles for Chemo-Photothermal Therapy | ADV FUNCT MATER | 徐建国,四川大学,华西医院,神经外科; | 3205.76 | 17 | 2021 | Therapeutic siCCR2 Loaded by Tetrahedral Framework DNA Nanorobotics in Therapy for Intracranial Hemorrhage | ADV FUNCT MATER | 游潮,四川大学,华西医院,神经外科; | 3141.76 | 18 | 2021 | A systematic review and meta-analysis of children with coronavirus disease 2019 (COVID-19) | J MED VIROL | 蔡春泉,天津儿童医院,,神经外科; | 3086.24 | 19 | 2021 | Biomedical applications of Pt(II) metallacycle/metallacage-based agents: From mono-chemotherapy to versatile imaging contrasts and theranostic platforms | COORDIN CHEM REV | 熊晓星,武汉大学,人民医院,神经外科; | 2970.72 | 20 | 2021 | Chinese Glioma Genome Atlas (CGGA) : A Comprehensive Resource with Functional Genomic Data from Chinese Glioma Patients | GENOM PROTEOM BIOINF | 江涛,首都医科大学,北京天坛医院,神经外科; | 2920.16 | 21 | 2021 | Hypoxia-induced acetylation of PAK1 enhances autophagy and promotes brain tumorigenesis via phosphorylating ATG5 | AUTOPHAGY | 刘幸,北京市神经外科研究所; | 2886.72 | 22 | 2021 | Conformation-dependent blockage of activated VWF improves outcomes of traumatic brain injury in mice | BLOOD | 张建宁,天津医科大学,总医院,神经外科; | 2870.88 | 23 | 2021 | Synergy of Immunostimulatory Genetherapy with Immune Checkpoint Blockade Motivates Immune Response to Eliminate Cancer | ADV FUNCT MATER | 高祥,四川大学,华西医院,神经外科; | 2821.76 | 24 | 2021 | Binaural processing deficit and cognitive impairment in Alzheimer's disease | ALZHEIMERS DEMENT | 赵国光,首都医科大学,宣武医院,神经外科; | 2795.52 | 25 | 2021 | NeuroD1 induces microglial apoptosis and cannot induce microglia-to-neuron cross-lineage reprogramming | NEURON | 毛颖,复旦大学上海医学院,华山医院,神经外科; | 2685.12 | 26 | 2021 | EIF4A3-induced circular RNA ASAP1 promotes tumorigenesis and temozolomide resistance of glioblastoma via NRAS/MEK1/ERK1-2 signaling | NEURO-ONCOLOGY | 尤永平,南京医科大学,第一附属医院,神经外科; | 2663.52 | 27 | 2021 | Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4 | AUTOPHAGY | 杭春华,南京大学,鼓楼医院,神经外科; | 2630.72 | 28 | 2021 | Embryonic Stem Cell Derived Small Extracellular Vesicles Modulate Regulatory T Cells to Protect against Ischemic Stroke | ACS NANO | 邓志锋,上海交通大学医学院,第六人民医院,神经外科; | 2590.08 | 29 | 2021 | Genetically encoded sensors enable micro- and nano-scopic decoding of transmission in healthy and diseased brains | MOL PSYCHIATR | 林丽,温州医科大学,神经外科; | 2539.2 | 30 | 2021 | De Novo Germline and Somatic Variants Convergently Promote Endothelial-to-Mesenchymal Transition in Simplex Brain Arteriovenous Malformation | CIRC RES | 曹勇,首都医科大学,附属北京天坛医院,神经外科; | 2537.92 | 31 | 2021 | Reduced Oligodendrocyte Precursor Cell Impairs Astrocytic Development in Early Life Stress | ADV SCI | 肖岚,第三军医大学,神经外科; | 2528.64 | 32 | 2021 | In Vivo Clonal Analysis Reveals Development Heterogeneity of Oligodendrocyte Precursor Cells Derived from Distinct Germinal Zones | ADV SCI | 刘冲,浙江大学,神经科学研究所,; | 2528.64 | 33 | 2021 | CRHCeA -> VTA inputs inhibit the positive ensembles to induce negative effect of opiate withdrawal | MOL PSYCHIATR | 王菲菲,复旦大学上海医学院,基础医学院,神经外科; | 2475.2 | 34 | 2021 | Rolling-translated EGFR variants sustain EGFR signaling and promote glioblastoma tumorigenicity | NEURO-ONCOLOGY | 张弩,中山大学,附属第一医院,神经外科; | 2471.52 | 35 | 2021 | PtdIns4P restriction by hydrolase SAC1 decides specific fusion of autophagosomes with lysosomes | AUTOPHAGY | 卢克锋,四川大学,神经外科; | 2438.72 | 36 | 2021 | Whole genome sequencing of skull-base chordoma reveals genomic alterations associated with recurrence and chordoma-specific survival | NAT COMMUN | 张亚卓,首都医科大学,天坛医院,神经外科; | 2424.48 | 37 | 2021 | M-CSF, IL-6, and TGF-beta promote generation of a new subset of tissue repair macrophage for traumatic brain injury recovery | SCI ADV | 胡锦,复旦大学上海医学院,华山医院,神经外科; | 2418.56 | 38 | 2021 | The adaptive transition of glioblastoma stem cells and its implications on treatments | SIGNAL TRANSDUCT TAR | 刘志雄,中南大学,湘雅医院,神经外科; | 2414.88 | 39 | 2021 | Pentraxin 3 secreted by human adipose-derived stem cells promotes dopaminergic neuron repair in Parkinson's disease via the inhibition of apoptosis | FASEB J | 郭洪波,南方医科大学,珠江医院,神经外科; | 2340.64 | 40 | 2021 | Collagen XI alpha 1 chain, a potential therapeutic target for cancer | FASEB J | 黄海燕,吉林大学第一医院,,神经外科; | 2340.64 | 41 | 2021 | Microglia modulation with 1070-nm light attenuates A beta burden and cognitive impairment in Alzheimer's disease mouse model | LIGHT-SCI APPL | 陈亮,复旦大学上海医学院,华山医院,神经外科; | 2336.48 | 42 | 2021 | TRIM22 activates NF-kappa B signaling in glioblastoma by accelerating the degradation of I kappa B alpha | CELL DEATH DIFFER | 李新钢,山东大学,齐鲁医院,神经外科; | 2290.72 | 43 | 2021 | Abnormal neocortex arealization and Sotos-like syndrome-associated behavior in Setd2 mutant mice | SCI ADV | 周严,武汉大学,生命科学学院,; | 2290.56 | 44 | 2021 | Kinectin 1 promotes the growth of triple-negative breast cancer via directly co-activating NF-kappaB/p65 and enhancing its transcriptional activity | SIGNAL TRANSDUCT TAR | 高祥,四川大学,华西医院,神经外科; | 2222.88 | 45 | 2021 | Regulatory mechanisms of immune checkpoints PD-L1 and CTLA-4 in cancer | J EXP CLIN CANC RES | 刘志雄,中南大学,湘雅医院,神经外科; | 2210.72 | 46 | 2021 | Circumventing Drug Resistance Pathways with a Nanoparticle-Based Photodynamic Method | NANO LETT | 李世亭,上海交通大学医学院,新华医院,神经外科; | 2204.64 | 47 | 2021 | Heat shock protein 22 modulates NRF1/TFAM-dependent mitochondrial biogenesis and DRP1-sparked mitochondrial apoptosis through AMPK-PGC1 alpha signaling pathway to alleviate the early brain injury of subarachnoid hemorrhage in rats | REDOX BIOL | 段传志,南方医科大学,珠江医院,神经外科; | 2109.76 | 48 | 2021 | Somatic MAP3K3 mutation defines a subclass of cerebral cavernous malformation | AM J HUM GENET | 曹勇,首都医科大学,附属北京天坛医院,神经外科; | 2087.84 | 49 | 2021 | The SARS-CoV-2 protein ORF3a inhibits fusion of autophagosomes with lysosomes | CELL DISCOV | 卢克锋,四川大学,神经外科; | 2080 | 50 | 2021 | Hypoxic Glioma Stem Cell-Derived Exosomes Containing Linc01060 Promote Progression of Glioma by Regulating the MZE1/c-Myc/HIF1 alpha Axis | CANCER RES | 熊南翔,武汉大学,中南医院,神经外科; | 2068.32 | 51 | 2021 | FUNDC1-dependent mitophagy induced by tPA protects neurons against cerebral ischemia-reperfusion injury | REDOX BIOL | 康春生,天津医科大学,总医院,神经病学研究所; | 2045.76 | 52 | 2021 | Human cortical encoding of pitch in tonal and non-tonal languages | NAT COMMUN | 吴劲松,复旦大学上海医学院,华山医院,神经外科; | 2040.48 | 53 | 2021 | Prokineticin-2 prevents neuronal cell deaths in a model of traumatic brain injury | NAT COMMUN | 季晶,南京医科大学,第一附属医院,神经外科; | 2040.48 | 54 | 2021 | Mg2TiO4 spinel modified by nitrogen doping as a Visible-Light-Active photocatalyst for antibacterial activity | CHEM ENG J | 骆纯,上海市同济医院,神经外科; | 2024.32 | 55 | 2021 | Functional maps of direct electrical stimulation-induced speech arrest and anomia: a multicentre retrospective study | BRAIN | 吴劲松,复旦大学上海医学院,华山医院,神经外科; | 2018.24 | 56 | 2021 | The Predictive Value of Monocytes in Immune Microenvironment and Prognosis of Glioma Patients Based on Machine Learning | FRONT IMMUNOL | 程全,中南大学,湘雅医院,神经外科; | 1988.64 | 57 | 2021 | Single-molecule optical mapping of the distribution of DNA phosphorothioate epigenetics | NUCLEIC ACIDS RES | 王连荣,武汉大学,神经外科; | 1977.76 | 58 | 2021 | Subthalamic and Pallidal Stimulations in Patients with Parkinson's Disease: Common and Dissociable Connections | ANN NEUROL | 孙伯民,上海交通大学医学院,瑞金医院,神经外科; | 1969.6 | 59 | 2021 | Multifunctionalized Gold Sub-Nanometer Particles for Sensitizing Radiotherapy against Glioblastoma | SMALL | 刘福生,首都医科大学,附属北京天坛医院,神经外科; | 1961.44 | 60 | 2021 | LncRNA-encoded microproteins: A new form of cargo in cell culture-derived and circulating extracellular vesicles | J EXTRACELL VESICLES | 张宏伟,首都医科大学,三博脑科医院,神经外科; | 1952 | 61 | 2021 | CircRNA EPHB4 modulates stem properties and proliferation of gliomas via sponging miR-637 and up-regulating SOX10 | MOL ONCOL | 刘景平,中南大学,湘雅医院,小儿神经外科; | 1904.16 | 62 | 2021 | Highly sensitive detection of malignant glioma cells using metamaterial-inspired THz biosensor based on electromagnetically induced transparency | BIOSENS BIOELECTRON | 穆宁,第三军医大学,第一附属医院,神经外科; | 1897.12 | 63 | 2021 | NEO100 enables brain delivery of blood-brain barrier impermeable therapeutics | NEURO-ONCOLOGY | 陈礼刚,西南医科大学,附属医院,神经外科; | 1895.52 | 64 | 2021 | Emerging mechanisms and targeted therapy of ferroptosis in cancer | MOL THER | 黄军,中南大学,湘雅医院,神经外科; | 1885.76 | 65 | 2021 | Intracellular RNA and nuclear DNA-dual-targeted tumor therapy via upconversion nanoplatforms with UCL/MR dual-mode bioimaging | CHEM ENG J | 王占峰,吉林大学,中日联谊医院,神经外科; | 1832.32 | 66 | 2021 | TGF-beta 1 modulates temozolomide resistance in glioblastoma via altered microRNA processing and elevated MGMT | NEURO-ONCOLOGY | 尤永平,南京医科大学,第一附属医院,神经外科; | 1831.52 | 67 | 2021 | Extracellular vesicles derived from hypoxic glioma stem-like cells confer temozolomide resistance on glioblastoma by delivering miR-30b-3p | THERANOSTICS | 尤永平,南京医科大学,第一附属医院,神经外科; | 1800.64 | 68 | 2021 | Rapid design and development of CRISPR-Cas13a targeting SARS-CoV-2 spike protein | THERANOSTICS | 康春生,天津医科大学,总医院,神经病学研究所; | 1800.64 | 69 | 2021 | Melanocortin 1 receptor attenuates early brain injury following subarachnoid hemorrhage by controlling mitochondrial metabolism via AMPK/SIRT1/PGC-1 alpha pathway in rats | THERANOSTICS | 徐维林,浙江大学医学院,神经外科; | 1800.64 | 70 | 2021 | Aptamer Generated by Cell-SELEX for Specific Targeting of Human Glioma Cells | ACS APPL MATER INTER | 康德智,福建医科大学,附属第一医院,神经外科; | 1785.28 | 71 | 2021 | A multi-modal delivery strategy for spinal cord regeneration using a composite hydrogel presenting biophysical and biochemical cues synergistically | BIOMATERIALS | 王贵怀,北京清华长庚医院,,神经外科; | 1778.72 | 72 | 2021 | CircCD44 plays oncogenic roles in triple-negative breast cancer by modulating the miR-502-5p/KRAS and IGF2BP2/Myc axes | MOL CANCER | 张弩,中山大学,附属第一医院,神经外科; | 1772.64 | 73 | 2021 | A novel hydrogel-based combination therapy for effective neuroregeneration after spinal cord injury | CHEM ENG J | 肖健,温州医科大学,神经外科; | 1768.32 | 74 | 2021 | Nestin(+)/CD31(+) cells in the hypoxic perivascular niche regulate glioblastoma chemoresistance by upregulating JAG1 and DLL4 | NEURO-ONCOLOGY | 林志雄,福建医科大学,附属第一医院,神经外科; | 1767.52 | 75 | 2021 | Loss of COPZ1 induces NCOA4 mediated autophagy and ferroptosis in glioblastoma cell lines | ONCOGENE | 李新钢,山东大学,齐鲁医院,神经外科; | 1753.44 | 76 | 2021 | Temporal order of signal propagation within and across intrinsic brain networks | P NATL ACAD SCI USA | 张凯,首都医科大学,附属北京天坛医院,功能神经外科; | 1743.36 | 77 | 2021 | CircURI1 interacts with hnRNPM to inhibit metastasis by modulating alternative splicing in gastric cancer | P NATL ACAD SCI USA | 胡珊珊,中国科学技术大学,附属第一医院,神经外科; | 1743.36 | 78 | 2021 | LncRNA PRADX-mediated recruitment of PRC2/DDX5 complex suppresses UBXN1 expression and activates NF-KB activity, promoting tumorigenesis | THERANOSTICS | 康春生,天津医科大学,总医院,神经病学研究所; | 1736.64 | 79 | 2021 | Exosomal miR-101-3p and miR-423-5p inhibit medulloblastoma tumorigenesis through targeting FOXP4 and EZH2 | CELL DEATH DIFFER | 李昊,复旦大学上海医学院,儿科医院,神经外科; | 1714.72 | 80 | 2021 | Theory of mind in adults with traumatic brain injury: A meta-analysis | NEUROSCI BIOBEHAV R | 王宏盛,东南大学,附属盐城市第三人民医院,神经外科; | 1709.44 | 81 | 2021 | DREAM: a database of experimentally supported protein-coding RNAs and drug associations in human cancer | MOL CANCER | 蔡金全,哈尔滨医科大学,附属第二医院,神经外科; | 1708.64 | 82 | 2021 | Inhibition of Dectin-1 Ameliorates Neuroinflammation by Regulating Microglia/Macrophage Phenotype After Intracerebral Hemorrhage in Mice | TRANSL STROKE RES | 陈高,浙江大学,附属第二医院,神经外科; | 1706.56 | 83 | 2021 | Endothelial Progenitor Cells Induce Angiogenesis: a Potential Mechanism Underlying Neovascularization in Encephaloduroarteriosynangiosis | TRANSL STROKE RES | 段炼,解放军总医院第五医学中心,,神经外科; | 1706.56 | 84 | 2021 | Knockdown of Arginyl-tRNA Synthetase Attenuates Ischemia-Induced Cerebral Cortex Injury in Rats After Middle Cerebral Artery Occlusion | TRANSL STROKE RES | 符荣,华中科技大学同济医学院,附属协和医院,神经外科; | 1706.56 | 85 | 2021 | Engineering microcapsules to construct vascularized human brain organoids | CHEM ENG J | 李维平,深圳市第二人民医院,,神经外科; | 1704.32 | 86 | 2021 | Engineering microcapsules to construct vascularized human brain organoids | CHEM ENG J | 李维平,深圳市第二人民医院,,神经外科; | 1704.32 | 87 | 2021 | Single-cell transcriptome and genome analyses of pituitary neuroendocrine tumors | NEURO-ONCOLOGY | 周大彪,首都医科大学,附属北京天坛医院,神经外科; | 1703.52 | 88 | 2021 | Exosomes derived from miR-188-3p-modified adipose-derived mesenchymal stem cells protect Parkinson's disease | MOL THER-NUCL ACIDS | 郭毅,中国医学科学院,北京协和医学院,神经外科; | 1701.12 | 89 | 2021 | ESC-sEVs Rejuvenate Aging Hippocampal NSCs by Transferring SMADs to Regulate the MYT1-Egln3-Sirt1 Axis | MOL THER | 邓志锋,上海交通大学医学院,第六人民医院,神经外科; | 1693.76 | 90 | 2021 | Hypoxia-induced PLOD1 overexpression contributes to the malignant phenotype of glioblastoma via NF-kappa B signaling | ONCOGENE | 姜阳,中国医科大学,附属第一医院,神经外科; | 1689.44 | 91 | 2021 | Astaxanthin ameliorates oxidative stress and neuronal apoptosis via SIRT1/NRF2/Prx2/ASK1/p38 after traumatic brain injury in mice | BRIT J PHARMACOL | 李伟,南京大学,鼓楼医院,神经外科; | 1684.8 | 92 | 2021 | Phosphoglycerate Mutase 5 Knockdown Alleviates Neuronal Injury After Traumatic Brain Injury Through Drp1-Mediated Mitochondrial Dysfunction | ANTIOXID REDOX SIGN | 刘伟,毕节市第一人民医院,,神经外科; | 1672.96 | 93 | 2021 | Cellular senescence in hepatocellular carcinoma induced by a long non-coding RNA-encoded peptide PINT87aa by blocking FOXM1-mediated PHB2 | THERANOSTICS | 张弩,中山大学,附属第一医院,神经外科; | 1672.64 | 94 | 2021 | PDIA5 is Correlated With Immune Infiltration and Predicts Poor Prognosis in Gliomas | FRONT IMMUNOL | 张李洋,中南大学,湘雅医院,神经外科; | 1668.64 | 95 | 2021 | High Levels of Circulating IL-8 and Soluble IL-2R Are Associated With Prolonged Illness in Patients With Severe COVID-19 | FRONT IMMUNOL | 王占祥,厦门大学,附属第一医院,神经外科; | 1668.64 | 96 | 2021 | CEBPA-AS1 Knockdown Alleviates Oxygen-Glucose Deprivation/Reperfusion-Induced Neuron Cell Damage by the MicroRNA 24-3p/BOK Axis | MOL CELL BIOL | 徐敏,南京中医药大学,附属昆山医院,神经外科; | 1668 | 97 | 2021 | Safety of Aspirin Use in Patients With Stroke and Small Unruptured Aneurysms | NEUROLOGY | 曹勇,首都医科大学,附属北京天坛医院,神经外科; | 1659.2 | 98 | 2021 | Self-Assembled Au Nanoparticle Arrays for Precise Metabolic Assay of Cerebrospinal Fluid | ACS APPL MATER INTER | 张昆,上海交通大学医学院,上海市儿童医院,神经外科; | 1657.28 | 99 | 2021 | Versatile metal-phenolic network nanoparticles for multitargeted combination therapy and magnetic resonance tracing in glioblastoma | BIOMATERIALS | 倪石磊,山东大学,齐鲁医院,神经外科; | 1650.72 | 100 | 2021 | Orphan nuclear receptor TLX promotes immunosuppression via its transcriptional activation of PD-L1 in glioma | J IMMUNOTHER CANCER | 毛捷,南方医科大学,深圳医院,神经外科; | 1650.08 |
|
|