2021年度中国妇产与生殖医学科领域高价值论文TOP100
以往我们对一篇论文的价值评估，是通过期刊影响因子或被引频次来判断，这种采用单一指标评判论文的学术价值因有失偏颇而广受诟病。北京同舟云网络信息技术有限公司创立了一种优选算法，综合考虑Metrics 期刊评分、论文被引频次、文献类型以及论文发表时间等多种因素，对每篇论文进行深度解析与计算，并赋予分值，以量化每篇论文的学术价值和影响力。本推荐表是在系统全面准确地统计中国机构作者发表的妇产与生殖医学领域国际论文的基础上（说明：妇产与生殖医学领域专家为主要完成人发表的全部论文均入选，不再筛选论文的内容主题），对每篇论文依上述方法进行计算并赋分排名而得出的，供相关学者学习、评判、参考和借鉴。
序号 | 年份 | 标题 | 期刊 | 主要完成人 | 论文评分 | 1 | 2021 | Live Birth with or without Preimplantation Genetic Testing for Aneuploidy | NEW ENGL J MED | 陈子江,山东大学,山东省立医院,生殖医学科; | 13321.6 | 2 | 2021 | A Lancet Commission on 70 years of women's reproductive, maternal, newborn, child, and adolescent health in China | LANCET | 乔杰,北京大学,第三医院,妇产科; | 11262.72 | 3 | 2021 | Platypus and echidna genomes reveal mammalian biology and evolution | NATURE | 周琦,浙江大学,生命科学研究院; | 8171.2 | 4 | 2021 | A single-cell map of intratumoral changes during anti-PD1 treatment of patients with breast cancer | NAT MED | 钱俊斌,浙江大学,附属妇产科学医院; | 8084.8 | 5 | 2021 | Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages | CELL RES | 钱俊斌,浙江大学,附属妇产科学医院; | 6737.12 | 6 | 2021 | Evaluation of sex-related hormones and semen characteristics in reproductive-aged male COVID-19 patients | J MED VIROL | 张铭,武汉大学,中南医院,生殖医学中心; | 6414.24 | 7 | 2021 | Camrelizumab plus apatinib in patients with high-risk chemorefractory or relapsed gestational trophoblastic neoplasia (CAP 01): a single-arm, open-label, phase 2 trial | LANCET ONCOL | 向阳,中国医学科学院,北京协和医院,妇产科; | 6019.36 | 8 | 2021 | Effectiveness of Sequential Chemoradiation vs Concurrent Chemoradiation or Radiation Alone in Adjuvant Treatment After Hysterectomy for Cervical Cancer The STARS Phase 3 Randomized Clinical Trial | JAMA ONCOL | 刘继红,中山大学,附属肿瘤医院,妇科; | 5567.84 | 9 | 2021 | Polymerization-Mediated Multifunctionalization of Living Cells for Enhanced Cell-Based Therapy | ADV MATER | 刘尽尧,上海交通大学医学院,仁济医院; | 5407.68 | 10 | 2021 | Plasmonic Alloys Reveal a Distinct Metabolic Phenotype of Early Gastric Cancer | ADV MATER | 钱昆,上海交通大学,生物医学工程学院; | 5343.68 | 11 | 2021 | Difference Between Medical and Nonmedical Students on Knowledge, Practice, and Attitude Towards the Human Papillomavirus Vaccine in China: a Cross-Sectional Study | J CANCER EDUC | 陶霞,北京大学,第一医院,妇产科; | 4878.4 | 12 | 2021 | Dynamics and Correlation Among Viral Positivity, Seroconversion, and Disease Severity in COVID-19 A Retrospective Study | ANN INTERN MED | 陈刚,华中科技大学,同济医学院附属同济医院,妇产科; | 4434.72 | 13 | 2021 | Decoding dynamic epigenetic landscapes in human oocytes using single-cell multi-omics sequencing | CELL STEM CELL | 郭帆,中国科学院; | 4406.88 | 14 | 2021 | Niraparib maintenance therapy in patients with platinum-sensitive recurrent ovarian cancer using an individualized starting dose (NORA): a randomized, double-blind, placebo-controlled phase III trial | ANN ONCOL | 吴向华,复旦大学上海医学院,肿瘤医院,肿瘤内科; | 4267.84 | 15 | 2021 | A novel defined pyroptosis-related gene signature for predicting the prognosis of ovarian cancer | CELL DEATH DISCOV | 漆洪波,重庆医科大学,附属第一医院,产科; | 4160.16 | 16 | 2021 | DevOmics: an integrated multi-omics database of human and mouse early embryo | BRIEF BIOINFORM | 闫丽盈,北京大学,第三医院,妇产科; | 4027.2 | 17 | 2021 | Pregnant women with SARS-CoV-2 infection are at higher risk of death and pneumonia: propensity score matched analysis of a nationwide prospective cohort (COV19Mx) | ULTRASOUND OBST GYN | 潘昭颐,香港中文大学,妇产科学系; | 3976.64 | 18 | 2021 | DeepHPV: a deep learning model to predict human papillomavirus integration sites | BRIEF BIOINFORM | 胡争,中山大学,附属第一医院,妇产科; | 3963.2 | 19 | 2021 | Integration and interplay of machine learning and bioinformatics approach to identify genetic interaction related to ovarian cancer chemoresistance | BRIEF BIOINFORM | 郭红燕,北京大学,第三医院,妇产科; | 3899.2 | 20 | 2021 | Global profiling of RNA-binding protein target sites by LACE-seq | NAT CELL BIOL | 孙青原,中国科学院; | 3767.04 | 21 | 2021 | Dissecting the epigenomic dynamics of human fetal germ cell development at single-cell resolution | CELL RES | 闫丽盈,北京大学,第三医院,妇产科; | 3729.12 | 22 | 2021 | Association of assisted reproductive technology, germline de novo mutations and congenital heart defects in a prospective birth cohort study | CELL RES | 沈洪兵,南京医科大学,公共卫生学院; | 3345.12 | 23 | 2021 | Molecular genetics of infertility: loss-of-function mutations in humans and corresponding knockout/mutated mice | HUM REPROD UPDATE | 杨镒魟,四川大学,华西第二医院,生殖医学中心; | 3276.48 | 24 | 2021 | Red blood cell membrane-camouflaged nanoparticles loaded with AIEgen and Poly(I:C) for enhanced tumoral photodynamic-immunotherapy | NATL SCI REV | 王世宣,华中科技大学,附属同济医院,妇科; | 3246.88 | 25 | 2021 | Deviated and early unsustainable stunted development of gut microbiota in children with autism spectrum disorder | GUT | 王益超,湖南省妇幼保健院; | 3235.04 | 26 | 2021 | Structural Basis of Potential Inhibitors Targeting SARS-CoV-2 Main Protease | FRONT CHEM | 金腾川,中国科学技术大学,生命科学学院; | 3224.8 | 27 | 2021 | Roles of CA125 in diagnosis, prediction, and oncogenesis of ovarian cancer | BBA-REV CANCER | 王育,上海交通大学医学院,仁济医院; | 3155.2 | 28 | 2021 | Aggregation-induced emission dots assisted non-invasive fluorescence hysterography in near-infrared IIb window | NANO TODAY | 张丹,浙江大学,属妇产科医院,生殖内分泌科; | 3141.12 | 29 | 2021 | Ultrabright NIR-II Emissive Polymer Dots for Metastatic Ovarian Cancer Detection | ADV SCI | 徐丛剑,复旦大学上海医学院,妇产科医院,上海市女性生殖内分泌相关疾病重点实验室; | 3040.64 | 30 | 2021 | Rapamycin prevents spontaneous abortion by triggering decidual stromal cell autophagy-mediated NK cell residence | AUTOPHAGY | 李大金,复旦大学上海医学院,妇产科医院; | 3014.72 | 31 | 2021 | NIR-light triggered dual-cascade targeting core-shell nanoparticles enhanced photodynamic therapy and immunotherapy | NANO TODAY | 王建六,北京大学,人民医院,妇科; | 3013.12 | 32 | 2021 | PADI2-Catalyzed MEK1 Citrullination Activates ERK1/2 and Promotes IGF2BP1-Mediated SOX2 mRNA Stability in Endometrial Cancer | ADV SCI | 张学森,南京医科大学,生殖医学国家重点实验室; | 2976.64 | 33 | 2021 | The role of the gut microbiome and its metabolites in metabolic diseases | PROTEIN CELL | 姜长涛,北京大学,基础医学院; | 2970.24 | 34 | 2021 | Melatonin improves the effect of cryopreservation on human oocytes by suppressing oxidative stress and maintaining the permeability of the oolemma | J PINEAL RES | 曹云霞,安徽医科大学,第一附属医院,妇产科; | 2947.36 | 35 | 2021 | PARP inhibition promotes ferroptosis via repressing SLC7A11 and synergizes with ferroptosis inducers in BRCA-proficient ovarian cancer | REDOX BIOL | 王静,湖南省肿瘤医院; | 2941.76 | 36 | 2021 | CXCL13 shapes immunoactive tumor microenvironment and enhances the efficacy of PD-1 checkpoint blockade in high-grade serous ovarian cancer | J IMMUNOTHER CANCER | 徐丛剑,复旦大学上海医学院,妇产科医院; | 2930.08 | 37 | 2021 | Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis | SIGNAL TRANSDUCT TAR | 赵健元,复旦大学,生命科学学院; | 2926.88 | 38 | 2021 | In situ formation of metal organic framework onto gold nanorods/mesoporous silica with functional integration for targeted theranostics | CHEM ENG J | 张翠莲,河南省人民医院,生殖医学中心; | 2920.32 | 39 | 2021 | Perturbations of genes essential for Mullerian duct and Wolffian duct development in Mayer-Rokitansky-Kuster-Hauser syndrome | AM J HUM GENET | 朱兰,中国医学科学院,北京协和医院,妇产科; | 2919.84 | 40 | 2021 | Protein Bait Hypothesis: circRNA-Encoded Proteins Competitively Inhibit Cognate Functional Isoforms | TRENDS GENET | 李笑天,复旦大学上海医学院,妇产科医院,产前诊断中心; | 2870.72 | 41 | 2021 | Inter- and Transgenerational Effects of Paternal Exposure to Inorganic Arsenic | ADV SCI | 丁国莲,上海交通大学医学院,国际和平妇幼保健院,辅助生育科; | 2848.64 | 42 | 2021 | A new emu genome illuminates the evolution of genome configuration and nuclear architecture of avian chromosomes | GENOME RES | 周琦,浙江大学,生命科学研究院; | 2788.8 | 43 | 2021 | The CNOT4 Subunit of the CCR4-NOT Complex is Involved in mRNA Degradation, Efficient DNA Damage Repair, and XY Chromosome Crossover during Male Germ Cell Meiosis | ADV SCI | 沙倩倩,广东省第二总医院,生殖中心; | 2784.64 | 44 | 2021 | ADGRG1 enriches for functional human hematopoietic stem cells following ex vivo expansion-induced mitochondrial oxidative stress | J CLIN INVEST | 滕银成,上海交通大学医学院,第六人民医院,妇产科; | 2770.4 | 45 | 2021 | A Fifteen-Gene Classifier to Predict Neoadjuvant Chemotherapy Responses in Patients with Stage IB to IIB Squamous Cervical Cancer | ADV SCI | 胡争,中山大学,附属第一医院,妇产科; | 2720.64 | 46 | 2021 | Autophagy signals orchestrate chemoresistance of gynecological cancers | BBA-REV CANCER | Wang, Chi Chiu,香港中文大学; | 2707.2 | 47 | 2021 | DNA methylome reveals cellular origin of cell-free DNA in spent medium of human preimplantation embryos | J CLIN INVEST | 乔杰,北京大学,第三医院,妇产科; | 2706.4 | 48 | 2021 | Regulation of exosome production and cargo sorting | INT J BIOL SCI | 朱小兰,江苏大学,第四附属医院 妇产科; | 2697.28 | 49 | 2021 | The JAK/STAT signaling pathway: from bench to clinic | SIGNAL TRANSDUCT TAR | 赵霞,四川大学,华西第二医院,妇科; | 2670.88 | 50 | 2021 | Autophagic elimination of ribosomes during spermiogenesis provides energy for flagellar motility | DEV CELL | 许文明,四川大学,华西第二医院; | 2661.44 | 51 | 2021 | Enhancing anti-PD-1 Immunotherapy by Nanomicelles Self-Assembled from Multivalent Aptamer Drug Conjugates | ANGEW CHEM INT EDIT | 刘尽尧,上海交通大学医学院,仁济医院,分子医学研究院; | 2645.44 | 52 | 2021 | Non-coding RNA-mediated autophagy in cancer: A protumor or antitumor factor? | BBA-REV CANCER | 程文俊,南京医科大学,第一附属医院,妇科; | 2643.2 | 53 | 2021 | Single-cell transcriptome profiling of the vaginal wall in women with severe anterior vaginal prolapse | NAT COMMUN | 朱兰,中国医学科学院,北京协和医院,妇产科; | 2616.48 | 54 | 2021 | Exosome-derived miR-142-5p remodels lymphatic vessels and induces IDO to promote immune privilege in the tumour microenvironment | CELL DEATH DIFFER | 王薇,广州医科大学,妇产科学; | 2610.72 | 55 | 2021 | PLAC8 promotes the autophagic activity and improves the growth priority of human trophoblast cells | FASEB J | 赵洪波,复旦大学上海医学院,妇产科医院; | 2596.64 | 56 | 2021 | Intelligent Molybdenum Disulfide Complexes as a Platform for Cooperative Imaging-Guided Tri-Mode Chemo-Photothermo-Immunotherapy | ADV SCI | 邢玲溪,上海交通大学医学院,新华医院,妇产科; | 2592.64 | 57 | 2021 | Single-cell RNA expression profiling of SARS-CoV-2-related ACE2 and TMPRSS2 in human trophectoderm and placenta | ULTRASOUND OBST GYN | 杨慧霞,北京大学,第一医院,妇产科; | 2568.64 | 58 | 2021 | Clinical and molecular characteristics of COVID-19 patients with persistent SARS-CoV-2 infection | NAT COMMUN | 李科珍,华中科技大学,同济医学院附属同济医院,妇产科; | 2552.48 | 59 | 2021 | Mucosal immunity-mediated modulation of the gut microbiome by oral delivery of probiotics into Peyer's patches | SCI ADV | 刘尽尧,上海交通大学医学院,仁济医院; | 2546.56 | 60 | 2021 | FBW7 suppresses ovarian cancer development by targeting the N-6-methyladenosine binding protein YTHDF2 | MOL CANCER | 吴小华,复旦大学上海医学院,肿瘤医院,肿瘤妇科; | 2540.64 | 61 | 2021 | Activin A increases human trophoblast invasion by upregulating integrin beta 1 through ALK4 | FASEB J | 马金龙,山东大学,附属生殖医院; | 2532.64 | 62 | 2021 | Physiology-Based Stretchable Electronics Design Method for Accurate Surface Electromyography Evaluation | ADV SCI | 谢臻蔚,浙江大学,医学院妇产科医院; | 2528.64 | 63 | 2021 | Nuclear m(6)A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos | PROTEIN CELL | 沈彬,南京医科大学,生殖医学国家重点实验室; | 2522.24 | 64 | 2021 | FTO demethylates m6A modifications in HOXB13 mRNA and promotes endometrial cancer metastasis by activating the WNT signalling pathway | RNA BIOL | 朱兰,中国医学科学院,北京协和医院,妇产科; | 2495.52 | 65 | 2021 | Structural characterization of the Plasmodium falciparum lactate transporter PfFNT alone and in complex with antimalarial compound MMV007839 reveals its inhibition mechanism | PLOS BIOL | 邓东,四川大学,华西第二医院; | 2475.52 | 66 | 2021 | Microenvironment-Protected Exosome-Hydrogel for Facilitating Endometrial Regeneration, Fertility Restoration, and Live Birth of Offspring | SMALL | 朱倩倩,上海交通大学医学院,第九人民医院,辅助生殖科; | 2473.44 | 67 | 2021 | A kaleidoscopic view of ovarian genes associated with premature ovarian insufficiency and senescence | FASEB J | 孙莹璞,郑州大学,第一附属医院,生殖医学中心; | 2468.64 | 68 | 2021 | Bone morphogenetic protein 2 upregulates SERPINE2 expression through noncanonical SMAD2/3 and p38 MAPK signaling pathways in human granulosa-lutein cells | FASEB J | 孙莹璞,郑州大学,第一附属医院,生殖医学中心; | 2468.64 | 69 | 2021 | Multifunctional Clip Strand for the Regulation of DNA Strand Displacement and Construction of Complex DNA Nanodevices | ACS NANO | 肖先金,华中科技大学同济医学院,计划生育研究所; | 2462.08 | 70 | 2021 | Cancer-Erythrocyte Hybrid Membrane-Camouflaged Magnetic Nanoparticles with Enhanced Photothermal-Immunotherapy for Ovarian Cancer | ACS NANO | 张蔚,武汉大学,中南医院,妇产科; | 2462.08 | 71 | 2021 | Cancer-secreted exosomal miR-1468-5p promotes tumor immune escape via the immunosuppressive of vessels | MOL THER | 王薇,广州医科大学,妇产科学; | 2461.76 | 72 | 2021 | IGF2BP1 overexpression stabilizes PEG10 mRNA in an m6A-dependent manner and promotes endometrial cancer progression | THERANOSTICS | 朱兰,中国医学科学院,北京协和医院,妇产科; | 2440.64 | 73 | 2021 | Analysis of sex hormones and menstruation in COVID-19 women of child-bearing age | REPROD BIOMED ONLINE | 艾继辉,华中科技大学,同济医学院附属同济医院; | 2439.84 | 74 | 2021 | A hypothetical role for autophagy during the day/night rhythm-regulated melatonin synthesis in the rat pineal gland | J PINEAL RES | 孙青原,中国科学院; | 2435.36 | 75 | 2021 | Paternal USP26 mutations raise Klinefelter syndrome risk in the offspring of mice and humans | EMBO J | 陈子江,山东大学,山东省立医院,生殖医学科; | 2431.84 | 76 | 2021 | Transcriptome Analysis in Yeast Reveals the Externality of Position Effects | MOL BIOL EVOL | 胡争,中山大学,附属第一医院,妇产科; | 2431.52 | 77 | 2021 | The trans-omics landscape of COVID-19 | NAT COMMUN | 陈刚,华中科技大学,同济医学院附属同济医院,妇产科; | 2424.48 | 78 | 2021 | Cellular and molecular landscape of mammalian sinoatrial node revealed by single-cell RNA sequencing | NAT COMMUN | 薛志刚,同济大学,医学院; | 2424.48 | 79 | 2021 | Oxidative phosphorylation enhances the leukemogenic capacity and resistance to chemotherapy of B cell acute lymphoblastic leukemia | SCI ADV | 郑俊克,上海交通大学医学院,医学院本部; | 2418.56 | 80 | 2021 | Bi-allelic mutations of DNAH10 cause primary male infertility with asthenoteratozoospermia in humans and mice | AM J HUM GENET | 曹云霞,安徽医科大学,第一附属医院,妇产科; | 2407.84 | 81 | 2021 | Magnetic Testis Targeting and Magnetic Hyperthermia for Noninvasive, Controllable Male Contraception via Intravenous Administration | NANO LETT | 丁伟华,南通大学; | 2396.64 | 82 | 2021 | Crystal structure of steroid reductase SRD5A reveals conserved steroid reduction mechanism | NAT COMMUN | 邓东,四川大学,华西第二医院; | 2360.48 | 83 | 2021 | Plasma cells shape the mesenchymal identity of ovarian cancers through transfer of exosome-derived microRNAs | SCI ADV | 周圣涛,四川大学,华西第二医院,妇产科; | 2354.56 | 84 | 2021 | METTL3-mediated maturation of miR-126-5p promotes ovarian cancer progression via PTEN-mediated PI3K/Akt/mTOR pathway | CANCER GENE THER | 杨永秀,兰州大学,第一医院,妇产科; | 2348.96 | 85 | 2021 | Parental methylome reprogramming in human uniparental blastocysts reveals germline memory transition | GENOME RES | 孙莹璞,郑州大学,第一附属医院,生殖医学中心; | 2340.8 | 86 | 2021 | Downregulated ribosomal protein L39 inhibits trophoblast cell migration and invasion by targeting E-cadherin in the placenta of patients with preeclampsia | FASEB J | 黄莉萍,南方医科大学,南方医院,妇产科; | 2340.64 | 87 | 2021 | Maternal RND3/RhoE deficiency impairs placental mitochondrial function in preeclampsia by modulating the PPAR gamma-UCP2 cascade | FASEB J | 岳晓婧,南方医科大学,南方医院,妇产科; | 2340.64 | 88 | 2021 | Chorionic villus-derived mesenchymal stem cells induce E3 ligase TRIM72 expression and regulate cell behaviors through ubiquitination of p53 in trophoblasts | FASEB J | 初怡静,青岛大学,附属医院,妇科; | 2340.64 | 89 | 2021 | circFAM120A participates in repeated implantation failure by regulating decidualization via the miR-29/ABHD5 axis | FASEB J | 颜军昊,山东大学,附属生殖医院,生殖科; | 2340.64 | 90 | 2021 | Furin is involved in uterine activation for labor | FASEB J | 倪鑫,第二军医大学; | 2340.64 | 91 | 2021 | An Open-label, Multicenter, Single-arm, Phase II Study of Fluzoparib in Patients with Germline BRCA1/2 Mutation and Platinum-sensitive Recurrent Ovarian Cancer | CLIN CANCER RES | 吴令英,中国医学科学院,肿瘤医院,妇瘤科; | 2335.84 | 92 | 2021 | Programmable Chromism and Photoluminescence of Spiropyran-Based Liquid Crystalline Polymer with Tunable Glass Transition Temperature | ANGEW CHEM INT EDIT | 吴郁,北京大学,第三医院 妇产科; | 2325.44 | 93 | 2021 | BCL7C suppresses ovarian cancer growth by inactivating mutant p53 | J MOL CELL BIOL | 张瑜,中南大学,湘雅医院; | 2272 | 94 | 2021 | Synergistic Therapy for Cervical Cancer by Codelivery of Cisplatin and JQ1 Inhibiting Plk1-Mutant Trp53 Axis | NANO LETT | 韩丽英,吉林大学第二医院妇产科 ; | 2268.64 | 95 | 2021 | DNMT3L promotes neural differentiation by enhancing STAT1 and STAT3 phosphorylation independent of DNA methylation | PROG NEUROBIOL | 王瑜,沈阳市妇幼保健院; | 2266.08 | 96 | 2021 | Obstetric and neonatal outcomes of pregnancies resulting from preimplantation genetic testing: a systematic review and meta-analysis | HUM REPROD UPDATE | 管一春,郑州大学,第三附属医院,生殖医学中心; | 2252.48 | 97 | 2021 | The Potent Antioxidant MitoQ Protects Against Preeclampsia During Late Gestation but Increases the Risk of Preeclampsia When Administered in Early Pregnancy | ANTIOXID REDOX SIGN | 童超,重庆医科大学,妇产科; | 2248.96 | 98 | 2021 | Single-cell multiomics sequencing reveals the functional regulatory landscape of early embryos | NAT COMMUN | 闫丽盈,北京大学,第三医院,妇产科; | 2232.48 | 99 | 2021 | Effects of SARS-CoV-2 infection on human reproduction | J MOL CELL BIOL | 乔杰,北京大学,第三医院,妇产科; | 2208 | 100 | 2021 | Pyk2 suppresses contextual fear memory in an autophosphorylation-independent manner | J MOL CELL BIOL | 索伦,上海交通大学医学院,第九人民医院,辅助生殖科; | 2208 |
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