姚广民,博士,华中科技大学副教授,博士生导师,湖北省“楚天学者”,中国科学院新疆理化技术研究所客座研究员,泰山医学院兼职教授。湖北省食品药品监督管理局药品注册现场核查员,武汉市药学会中药与天然药物专业委员会委员。山东省东明县人。主要从事天然药物化学与创新药物的研究与开发。先后主持国家自然科学基金2项、国家重大新药创制专项1项、省部级、校级科研项目10余项。指导教育部和华中科技大学大学生创新性实验计划6项。在Organic Letters, Journal of Biological Chemistry, Journal of Natural Products, Phytochemistry, Molecules, J. Braz. Chem. Soc., Biochemical Systematics and Ecology, 有机化学, 药学学报等国内外药学类期刊上发表论文50余篇。Organic Letters, Molecules, Fitoterapia等期刊特约评审人。承担本科生《天然药物化学》和《波谱解析》,研究生《天然药物研究方法》和《波谱解析》课程。学习与工作经历1995.9–1999.7:曲阜师范大学,化学系,本科生,获学士学位。1999.9–2002.7:南开大学,元素有机化学研究所,硕士研究生,获硕士学位。2002.9–2005.7:中国科学院上海药物研究所,博士研究生,获博士学位。2005.7–2006.2:石家庄制药集团药物研究院,新药开发项目组长,研究员。2006.2–2007.12:美国明尼苏达大学(University of Minnesota),博士后。2007.12–2008.11:美国夏威夷太平洋大学(Hawaii Pacific University),博士后。2008.11–2009.5:美国夏威夷太平洋大学,研究员(Research Scientist)。2009.6–至今:华中科技大学同济医学院药学院,副教授,硕士生导师。2010.9–至今:华中科技大学同济医学院药学院,博士生导师。2011.3–至今:湖北省食品药品监督管理局药品注册现场核查员。2011.4–至今:湖北省楚天学者计划“楚天学子”。2012.6–至今:泰山医学院兼职教授。2014.5–至今:中国科学院新疆理化技术研究所客座研究员。研究方向天然药物化学与创新药物的研究与开发。主要是从传统中草药、海洋生物、微生物等天然药物资源中寻找结构新颖、具有抗癌、消炎、抗老年痴呆和降血糖等生物活性显著的天然产物,并以此为先导化合物,通过化学结构改造、化学衍生化等方法从中发现高效低毒的新药候选化合物,开发出具有自主知识产权的创新药物。主持的科研项目[1]. 国家科技部“重大新药创制专项”。项目编号:2013ZX09103-001-020,2013.1–2015.12,负责人。[2]. 国家自然科学基金面上项目。No. 31170323,2012.1–2015.12,负责人。[3]. 国家自然科学基金青年基金。No. 81001368,2011.1–2013.12,负责人。[4]. 教育部留学回国人员科研启动基金。2010-1561-第40批。2011.1–2013.12,,负责人。[5]. 教育部高等学校博士学科点专项科研基金(新教师类)。No. 20100142120069,2011.1-2012.12,负责人。[6]. 湖北省自然科学基金。No. 2010CDB03206。2010.6–2011.12,负责人。[7]. 湖北省卫生厅青年科技人才项目。No. QJX2010-2,2011.1–2012.12,负责人。[8]. 武汉市青年科技晨光计划。No. 201271031389,2012.1–2014.12,负责人。[9]. 华中科技大学人才引进基金。2009.6–2012.7,负责人。[10]. 华中科技大学医科科研基金。2010.1–2011.12,负责人。[11]. 华中科技大学自主创新基金,No.HUST 2014QN131,2014.1–2015.12,负责人。[12]. 华中科技大学自主创新基金,No. HUST2012QN003,2012.1–2013.12,负责人。[13]. 天然药物化学与资源评价湖北省重点实验室开放基金。2010.9–2012.8,负责人。[14]. 华中科技大学研究生国际化课程《天然药物化学研究》,2011.6.1–2011.7.2,课程负责人。[15]. 教育部国家大学生创新性实验计划,照山白花的化学成分和生物活性研究(陈洪文),2009.12-2010.12,指导教师。[16]. 教育部国家级大学生创新创业训练计划项目,基于抑制Streptomyces 85E气生菌丝生成寻找山藿香中的活性成分(司岩岩),2012.6-2013.5,指导教师。[17]. 华中科技大学大学生创新性实验计划,基于抑制Streptomyces 85E气生菌丝生成寻找山藿香中的活性成分(司岩岩),2011.7-2012.6,指导教师。[18]. 华中科技大学2012年第一批大学生创新创业训练计划项目,药用植物葱莲中活性生物碱成分研究(张晋博),2012.1-2012.12,指导教师。[19]. 华中科技大学2013年第一批大学生创新创业训练计划项目,川桂叶化学成分和生物活性研究(邱瑞琪),2013.1-2013.12,指导教师。[20]. 华中科技大学2013年第二批大学生创新创业训练计划项目,兴安杜鹃化学成分和生物活性研究(卢韶华),2013.7-2013.6,指导教师。近五年发表学术论文[1]. Zeng, Junfen; Xue, Yongbo; Shu, Penghua; Qian, Huiqin; Sa, Rongjian; Xiang, Ming; Li, Xiao-Nian; Luo, Zengwei; Yao, Guangmin* (通讯作者); Zhang, Yonghui*. Diterpenoids with Immunosuppressive Activities from Cinnamomum cassia. Journal of Natural Products 2014, 77 (8), 1948–1954. (SCI, A类,IF = 3.947)[2]. Zhang, Mengke; Xie, Yangyang; Zhan, Guanqun; Lei, Liang; Shu, Penghua; Chen, Yongli; Xue,Yongbo; Luo, Zengwei; Wan, Qian; Yao, Guangmin* (通讯作者); Zhang, Yonghui.* Grayanane and leucothane diterpenoids from Rhododendron micranthum and their immunomodulatory activities. Phytochemistry 2014, in press, Manuscript ID PHYTOCHEM-D-14-00093 (SCI, A类,IF = 3.5).[3]. Guo, Guoli#; Yao, Guangmin# (共同第一); Zhan, Guanqun; Ye, Qi; Jiang, Jue; Hu Yufeng; Qing, Guoliang; Zhang, Yonghui; Liu Hudan. N-methylhemeanthidine chloride, a novel Amaryllidaceae alkaloid, inhibits pancreatic cancer cell proliferation via down-regulating AKT activation. Toxicology and Applied Pharmacology 2014, in press, Manuscript ID TAAP-D-14-00520R1 (SCI, A类,IF = 3.63). [4]. 张孟科,詹冠群,雷亮,薛永波,罗增伟,万谦,姚广民 (通讯作者)*,张勇慧. 照山白枝叶化学成分研究[OL]. [2014-01-28]..中国科技论文在线,http://www.paper.edu.cn/releasepaper/content/201401-1244. [5]. 张孟科,朱焰,詹冠群,薛永波,罗增伟,万谦,姚广民 (通讯作者)*,张勇慧. 照山白花水溶性成分研究[OL]. [2014-01-28]..中国科技论文在线,http://www.paper.edu.cn/releasepaper/content/201401-1247. [6]. Tang, Ying; Xue, Yong-bo; Zhou, Lei; Zhang, Jin-wen; Yao, Guang-min; Luo, Zeng-wei; Du Guang*; Zhang, Yong-hui*. New norclerodane diterpenoids from the tubers of Dioscorea bulbifera. Chemical Pharmaceutical Bulletin 2014, 62 (7), 719–724. (SCI, B类,IF = 1.375). [7]. Hu, Zhengxi; Lai, Yongji; Zhang, Jinwen; Wu, Ye; Luo, Zengwei; Yao, Guangmin; Xue, Yongbo;* Zhang, Yonghui*. Phytochemical and chemotaxonomic studies on Phyllanthus urinaria. Biochemical Systematics and Ecology 2014, 56, 60–64. (SCI, IF = 1.153).[8]. Zhu, Hucheng; Huan, Lijun; Chen, Chunmei; Yang, Jing; He, Jiangbo; Chen, Yong; Yao, Guangmin; Luo, Zengwei; Xue, Yongbo*; Zhang, Yonghui*. A pair of unprecedented cyclohexylethanoid enantiomers containing unusual trioxabicyclo[4.2.1]nonane ring from Clerodendrum bungei. Tetrahedron Letters 2014, 55 (14), 2277–2279. (SCI, B类,IF = 2.391). [9]. Yang, Yingda; Hu, Zhengxi; Luo, Zengwei; Xue, Yongbo; Yao, Guangmin; Wang, Yanyan;* Zhang, Yonghui.* A New Sesquilignan Glucoside from Uraria sinensis. Molecules 2014, 19, 1178–1188. (SCI, B类,IF = 2.095). [10]. Zhang, Mengke; Zhu, Yan; Shu, Penghua; Sa, Rongjian; Lei, Liang; Xiang, Ming; Xue,Yongbo; Luo, Zengwei; Wan, Qian; Yao, Guangmin* (通讯作者); Zhang, Yonghui.* Micrantone A, a New Diterpenoid with an Unprecedent Carbon Skeleton from Rhododendron micranthum. Organic Letters 2013, 15 (12), 3094–3097. (SCI, A类,IF = 6.324) [11]. Shu, Penghua; Wei, Xialan; Xue, Yongbo; Li, Weijie; Zhang, Jinwen; Xiang, Ming; Zhang, Mengke; Luo, Zengwei; Li, Yan; Yao, Guangmin* (通讯作者); Zhang, Yonghui*. Wilsonols A–L, Megastigmane Sesquiterpenoids from the Leaves of Cinnamomum wilsonii. Journal of Natural Products 2013, 76 (7), 1303–1312 (SCI, A类,IF = 3.947).[12]. Lai, Yongji; Xue,Yongbo; Zhang, Mengke; Zhang, Jinwen; Tang, Wei; Liu, Junjun; Lei, Liang; Yan, Juming; Luo, Zengwei; Zuo, Jianping; Li, Yan; Yao, Guangmin* (通讯作者); Zhang, Yonghui*. Scapiformolactones A–I: germacrane sesquiterpenoids with an unusual Δ3-15,6-lactone moiety from the whole plants of Salvia scapiformis Phytochemistry 2013, 96, 378–388. (SCI, A类,IF = 3.5). [13]. Zheng, Heng; Chen, Qiong; Zhang, Mengke; Lai, Yongji; Lei, Liang; Shu, Penghua; Xue, Yongbo; Luo, Zengwei; Zhang, Jinwen; Li, Yan; Yao, Guangmin* (通讯作者); Zhang, Yonghui.* Cytotoxic ent-Kaurane Diterpenoids from Salvia cavaleriei. Journal of Natural Products 2013, 76 (12) 2253–2262. (SCI, A类,IF = 3.285). [14]. Hao, Xincai; Zhang, Jinwen; Xia, Guangxin; Xue, Yongbo; Luo, Zengwei; Si, Yanyan; Yao, Guangmin* (通讯作者); Zhang, Yonghui.* A New Triterpenoid from Teucrium viscidum. Molecules 2013, 18 (1), 1262–1269. (SCI, B 类, IF = 2.428)[15]. Lai, Yongji; Ding, Shuiping; Qian, Huiqin; Zhang, Jinwen; Xue, Yongbo; Luo, Zengwei; Yao, Guangmin* (通讯作者); Zhang, Yonghui.* A New Lignan Glucoside from the Whole Plants of Salvia Scapiformis. Molecules 2013, 18 (9), 11377–1138. (SCI, B 类, IF = 2.428)[16]. Hao, Xincai; Zhang, Jinwen; Zhan, Guanqun; Xue, Yongbo; Luo, Zengwei; Yao, Guangmin* (通讯作者); Zhang, Yonghui.* Chemical constituents from Teucrium viscidum. Biochemical Systematics and Ecology 2013, 51, 78–82. (SCI, C类,IF = 1.153).[17]. Wei, Xialan; Shu, Penghua; Liu, Tingting; Xiang, Ming; Zhang, Jinwen; Xue, Yongbo; Luo, Zengwei; Yao, Guangmin* (通讯作者); Zhang, Yonghui*. Steroids and Phenylpropanoids with Immunomodulatory Activities from the Stem Barks of Cinnamomum wilsonii. Chinese Journal of Organic Chemistry. 2013, 33 (6), 1273–1278. (SCI, C 类, IF = 0.741).[18]. 曾红,钱慧琴,梁兆昌,杨亚军,褚洪标,张勇慧,姚广民* (通讯作者). 云锦杜鹃化学成分研究 中草药,2013, 44 (22), 3123–3126. [19]. Qin, Dongmei; Wen, Zhiping; Nie, Yaru; Yao, Guangmin. Effect of Cichorium Glandulosum extracts on CCl4-induced hepatic fibrosis. Iran Red Crescent Med J. 2013, 15(12), e10908. [20]. Hu, Zhengxi; Xue, Yongbo; Yao, Guangmin; Luo, Zengwei; Wang, Yanyan;Yonghui Zhang. Chemical constituents from the leaves of Premna microphylla Turcz. Journal of Chinese Pharmaceutical Sciences 2013, 22 (5), 431–434.[21]. 王富乾,张锦文,姚广民,陈旖湛,薛永波,罗增伟,张耕,张勇慧. 乌桕叶化学成分研究. 中国药学杂志, 2013, 48 (22), 1908–1911. [22]. Luo, Zengwei; Yang, Bo; Zhong, Cheng; Tang, Fang; Yuan, Ming; Xue, Yongbo; Yao Guangmin; Zhang, Jingwen; Zhang, Yonghui*. A dual-channel probe for selective fluoride determination and application in live cell imaging. Dyes and Pigments. 2013, 97, 52–57 (IF 3.126).[23]. Guo, Jieru; Zhang, Jinwen; Yao, Guangmin; Liao, Mei; Chen, Huadong; Yang, Xixiong; Zhang, Yonghui.* Hepatoprotective activity of the ethanol extract of Sarcopyramis Nepalensis. Journal of Huazhong University of Science and Technology, Medical Sciences 2012, 32 (6), 844–848. (SCI, C 类, IF = 0.581)[24]. Luo, Zengwei; Wang, Fuqian; Zhang, Jinwen; Li, Xingyao; Zhang Mengke; Hao, Xincai; Xue, Yongbo; Li, Yan; Horgen, F. David; Yao, Guangmin* (通讯作者); Zhang, Yonghui.* Cytotoxic Alkaloids from the Whole Plants of Zephyranthes candida. Journal of Natural Products 2012, 75 (12), 2113–2120. (SCI, A类,IF = 3.285)[25]. Guo, Jieru; Zhang, Jinwen; Shu, Penghua; Kong, Lingmei; Hao, Xincai; Xue, Yongbo; Luo, Zengwei; Li, Gao; Li, Yan; Yao, Guangmin* (通讯作者); Zhang, Yonghui.* Two New Diterpenoids from the Buds of Wikstroemia chamaedaphne. Molecules 2012, 17 (6), 6424–6433. (SCI, C 类, IF = 2.428) [26]. Zierler, Susanna; Yao,Guangmin; Zhang, Zheng; Kuo, W. Cedric; Poerzgen, Peter; Penner, Reinhold; Horgen, F. David; Fleig Andrea. Waixenicin A inhibits cell proliferation through magnesium-dependent block of TRPM7. Journal of Biological Chemistry 2011, 286 (45), 39328–39335. (SCI, A 类, IF = 4.651)[27]. Yao, Guangmin; Sebisubi, Fred Musoke; Christopher Voo, Lok Yung, Ho, Coy Choke; Tan, Ghee Teng; Chang, Leng Chee. Citrinin Derivatives from the Soil Filamentous Fungus Penicillium sp. H9318. Journal of the Brazilian Chemical Society 2011, 22 (6), 1125–1129. (SCI, B 类, IF = 1.283)[28]. 张明伟, 张锦文, 杨颖达,罗增伟,姚广民,张勇慧. 紫芫花化学成分的研究. 中国药学杂志. 2011, 46 (22), 1704–1706. [29]. Hou, Wen-Rui; Su, Zhi-Qiang; Pi, Hui-Fang; Yao, Guang-Min; Zhang, Peng; Luo, Xiang; Xie, Sheng-Nan; Xiang, Ming. Immunosuppressive constituents from Urtica dentata Hand. Journal of Asian Natural Products Research. 2010, 12 (8), 707–713. (SCI, B 类, IF = 0.948)[30]. 张锦文, 郭洁茹, 唐菲, 张小琼, 徐江涛, 姚广民, 张勇慧. 大接骨丹化学成分研究. 中药材 2010, 33 (11), 1725–1727.