Signaling in the living systems : gene keys and gene locks-Reference-Cited by-同舟云学术

Signaling in the living systems : gene keys and gene locks

Published:2023-09-01 Issue: Volume:32 Page:41-46
ISSN:2415-3826
Container-title:Faktori eksperimental'noi evolucii organizmiv
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Short-container-title:Fakt. eksp. evol. org.

Author:

Kurchii B. A.

Abstract

This article briefly discusses the complex and intricate mechanisms of the functioning of signaling systems between the plasma membrane and the nucleus in the living organisms. An alternative model of DNA packaging is described. The milestone of this model is assumption that DNA winds not around the histone octamer: it is organized between two layers of nucleosomes. The basic structure of chromosomes is a triplet of nucleosomes. A single nucleosome is a parallelepiped in shape (11x11x6 nm). An alternative to protein receptors is proposed receptors composed from nucleic acid (DNA, RNA), called gene keys, that open the code (gene lock) of gene/cluster at the promoter.

Publisher

Institute of Molecular Biology and Genetics (NAS Ukraine)

Subject

General Medicine

Reference13 articles.

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5. Kurchii B. A. The three-dimensional architecture of chromatin: zigzag-shaped band of DNA is disposed between two layers of nucleosomes forming a chromosome. Ukr Bioorg Acta. 2004. Vol. 1 (No. 1). P. 67–73.