Antibiotic Resistance of Klebsiella Pneumoniae Strains Isolated from the Blood of Patients with COVID-19

Abstract

A retrospective analysis of case histories and the results of microbiological blood tests of patients with coronavirus infection COVID-19 who were treated in the infectious diseases hospital of the city clinical hospital №52 in Moscow in 2020 was carried out. The sensitivity to the main antibacterial agents was determined for each isolate of Klebsiella pneumoniae, the phenotype of each pathogen was characterized (MDR, XDR, PDR). The results of the study were statistically processed and presented in the form of a register of bacteremia cases. Most pathogens (79%) were isolated from the blood of patients who were treated in intensive care units. Klebsiella pneumoniae ranked first in the structure of bacteremias, the frequency of occurrence of the pathogen was 41,1% (282/686). Only 4% of Klebsiella pneumoniae isolates were sensitive to antibiotics; the phenotypes of antibiotic-resistant strains were MDR – 16%, XDR – 76%, PDR – 4%. Most of the isolated Klebsiella pneumoniae strains were carbapenem-resistant (85,4%), 11,1% were colistin-resistant, 10,6% of the isolates were extended spectrum β-lactamase producers.