Comorbidity and multimorbidity in patients with chronic hepatitis C

Author:

Saranskaya Ya. E.1,Kiseleva L. M.1,Sachek A. A.1

Affiliation:

1. Ulyanovsk State University

Abstract

The aim of the study was to analyze comorbidity in patients who underwent a course of antiviral therapy for chronic hepatitis C with direct antiviral drugs.Materials and methods: 288 patients diagnosed with chronic hepatitis C with stages of liver fibrosis from F1 to F4 according to the METAVIR scale, various genotypes, who underwent antiviral therapy with direct antiviral drugs in the period from 2018 to 2021, were under observation, with an analysis of comorbid and multimorbid diseases.Results of the study: most often in these patients, regardless of gender and antiviral therapy regimen, lesions of the gastrointestinal tract were registered in the form of various inflammatory diseases, as well as non-alcoholic fatty liver disease. In second place in terms of frequency of occurrence, diseases of the endocrine system were diagnosed, primarily due to the development of metabolic syndrome, as well as damage to the thyroid gland, as an extrahepatic manifestation of chronic HCV infection. Slightly less marked diseases of the cardiovascular system. A relationship was found between the number of comorbid diseases and the body mass index, with an increase in which the stage of liver fibrosis progresses.Conclusions: The frequency of comorbidity and multimorbidity in patients with chronic HCV infection is significantly higher than in uninfected patients. Patients with chronic hepatitis C with advanced stages of liver fibrosis (F3 and F4 according to the MEVIR scale) with overweight and obesity of varying severity are characterized by the highest incidence of comorbidities. A variety of extrahepatic manifestations of chronic hepatitis C determine the polymorbid profile of the patient.

Publisher

SPRIDA

Subject

Infectious Diseases

Reference17 articles.

1. Drapkina, O.M. Komorbidnost’, mul’timorbidnost’, dvojnoj diagnoz – sinonimy ili raznye ponjatija?/ O.M. Drapkina, A.M. Shutov, E.V. Efremova// Kardiovaskuljarnaja terapija i profilaktika. – 2019. – 18(2):65-69. –URL: https://doi.org/10.15829/1728-8800-2019-2-65-69 (data obrashhenija: 29.04.2022).

2. Tarlovskaja, E.I. Komorbidnost’ i polimorbidnost’ -sovremennaja traktovka i nasushhnye zadachi, stojashhie pered terapevticheskim soobshhestvom./ E.I. Tarlovskaja // Kardiologija. – 2018. – 58(9S):29-38. –URL: https://doi.org/10.18087/cardio.2562 (data obrashhenija: 29.04.2022).

3. Pimenov, N.N. Gepatit S i ego ishody v Rossii: analiz zabolevaemosti rasprostranennosti i smertnosti do nachala programmy jeliminacii infekcii / N.N. Pimenov, S.V. Komarova, I.V. Karandashova, N.N. Capkova, E.V. Volchkova, V.P. Chulanov // Infekcionnye bolezni. – 2018. – 16 (3) – S. 37–45. URL: https://doi.org/10.20953/1729-9225-2018-3-37-45 (data obrashhenija: 29.04.2022).

4. Cooper, C. L., HCV-infected individuals have higher prevalence of comorbidity and multimorbidity: a retrospective cohort study./ C. L Cooper., C .Galanakis, J.Donelle, J. C.Kwong, R.Boyd, L.Boucher, C. E. Kendall. // BMC Infect Dis. – 2019. – 19 (1): 712. – URL: https://doi.org/10.1186/s12879–019–4315–6 (дата обращения: 30.04.2022).

5. Chen,Y. Different hepatitis C virus infection status show a significant risk of developing type 2 diabetes mellitus: a network meta-analysis/Y. Chen, Ji. Hanzhen, Shao Jianguo et al. // Digestive Diseases and Sciences. – 2020. – Jul;65(7):1940-1950. – URL: https://doi.org/10.1007/s10620-019-05918-7 (дата обращения: 30.04.2022).

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3