Pediatric multisystem inflammatory syndrome associated with a new coronavirus infection: unresolved issues

Author:

Lobzin Yu. V.1,Vilnits A. A.2,Kostik M. M.3,Bekhtereva M. K.2,Uskov A. N.4,Skripchenko N. V.2,Babachenko I. V.2,Ivanov D. O.3,Alexandrovich Yu. S.3,Konstantinova Yu. E.4,Dondurei E. A.5,Konev A. I.2,Karasev V. V.4

Affiliation:

1. Pediatric Research and Clinical Center for Infectious Disease; North-Western State Medical University named after I. I. Mechnikov; Military Medical Academy named after S.M. Kirov

2. Pediatric Research and Clinical Center for Infectious Disease; Saint-Petersburg State Pediatric Medical University

3. Saint-Petersburg State Pediatric Medical University

4. Pediatric Research and Clinical Center for Infectious Disease

5. Research Institute of Influenza named after A.A. Smorodintsev; City Children’s Hospital № 5 named after N.F. Filatov

Abstract

Since March 2020, the first reports have appeared about the increasing, almost everywhere, number of children who have undergone a new coronovirus infection caused by SARS-Cov-2 with a symptom complex resembling the manifestations of Kawasaki disease. A special feature of the clinical manifestations of this syndrome, which is called “Pediatric multisystem inflammatory syndrome associated with COVID-19”, is the high incidence of life-threatening conditions caused by the sharp development of arterial hypotension against the background of cardiogenic or vasogenic shock.In St. Petersburg, since the end of November 2020, there has been a sharp surge in admissions of children to the ICU of various hospitals with the clinic of Pediatric multisystem inflammatory syndrome, who have laboratory confirmation of the transferred COVID-19.The purpose of this article is to attract the attention of doctors of various profiles, to combine efforts to study this pathology, to determine the criteria for verifying the diagnosis, optimal treatment regimens and dispensary monitoring of patients who have been ill.

Publisher

SPRIDA

Subject

Infectious Diseases

Reference17 articles.

1. Royal College of Paediatric and Child Health. Guidance: paediatric multisystem inflammatory syndrome temporally associated with COVID-19. https://www.rcpch.ac.uk/resources/guidance-paediatric-multisystem-inflammatory-syndrometemporally-associated-covid-19. Published 2020.

2. Kelvin, Alyson A., and Scott Halperin. “COVID-19 in children: the link in the transmission chain.” The Lancet Infectious Diseases 20.6 (2020): 633-634.

3. Leidman, Eva, et al. “COVID-19 trends among persons aged 0–24 years—united states, march 1–december 12, 2020.” Morbidity and Mortality Weekly Report 70.3 (2021): 88.14]

4. Toubiana J, Poirault C, Corsia A, Bajolle F, Fourgeaud J, Angoulvant F, et al. Kawasaki-like multisystem inflamяmatory syndrome in children during the covid-19 pandemic in Paris, France: prospective observational study. BMJ. 2020; 369: m2094.

5. Ravelli A, Minoia F, Davì S, Horne A, Bovis F, Pistorio A, et al. 2016 Classification Criteria for Macrophage ActivationSyndrome Complicating Systemic Juvenile Idiopathic Arthritis: A European League Against Rheumatism/American College of Rheumatology/Paediatric Rheumatology International Trials Organisation Collaborative Initiative. Ann. Rheum. Dis. 2016;75 (3): 481–489.

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