Affiliation:
1. Central Research Institute of Epidemiology; University Clinic «H-Clinic»
2. Central Research Institute of Epidemiology
3. University Clinic «H-Clinic»; Peoples Friendship University of Russia
Abstract
This article provides an overview of the existing literature on the pharmacogenetic determinants of exposure and toxicity of antiretroviral drugs, as well as on genetic markers associated with the rate of disease progression. In addition, this article looks at current clinical opportunities as well as genetics in HIV drug development. Large-scale, integrated approaches to the genome are expected to significantly change the knowledge landscape in the future.