The Efficacy of Pre-Treatment Proton Pump Inhibitors in the Eradication of Helicobacter pylori

Abstract

Objective: Proton pump inhibitors significantly reduce Helicobacter pylori colonization and provide recovery in its activity and inflammation. We investigated; the effects of eradication initiated 28 days after proton pump inhibitor treatment and eradication initiated simultaneously with proton pump inhibitor treatment, on treatment success rates of Helicobacter pylori. Material and Methods: The study took place at our tertiary care hospital, where 42 patients in the study group were given oral lansoprazole treatment for 28 days followed by eradication treatment and 41 patients in the control group were given both treatments simultaneously. Eradication success was monitored using Helicobacter pylori polyclonal antigen stool tests. Results: A total of 83 participants, aged between 8 and 18 years, tested positive for Helicobacter pylori. The mean age of the participants was 15.14 ± 2.01 years. The Helicobacter pylori cure rate was found to be 92.9% in the study group and 92.7% in the control group. There were no significant differences observed between the two groups in terms of eradicating Helicobacter pylori (p=0.976). Conclusion: We found no significant differences in Helicobacter pylori treatment success rates with modified proton pump inhibitor usage in children.