Advances in Subcellular Accumulation Design for Recombinant Protein Production in Tobacco

Author:

Song Shi-Jian12ORCID,Diao Hai-Ping1,Guo Yong-Feng1,Hwang Inhwan34

Affiliation:

1. Tobacco Research Institute, Chinese Academy of Agricultural Sciences, Qingdao, China.

2. Beijing Life Science Academy (BLSA), Beijing, China.

3. Department of Life Science, Pohang University of Science and Technology, Pohang, Republic of Korea.

4. BioApplications Inc., Pohang, Republic of Korea.

Abstract

Plants and their use as bioreactors for the generation of recombinant proteins have become one of the hottest topics in the field of Plant Biotechnology and Plant Synthetic Biology. Plant bioreactors offer superior engineering potential compared to other types, particularly in the realm of subcellular accumulation strategies for increasing production yield and quality. This review explores established and emerging strategies for subcellular accumulation of recombinant proteins in tobacco bioreactors, highlighting recent advancements in the field. Additionally, the review provides reference to the crucial initial step of selecting an optimal subcellular localization for the target protein, a design that substantially impacts production outcomes.

Funder

Agricultural Science and Technology Innovation Program

Special Projects of the Central Government in Guidance of Local Science and Technology Development

Publisher

American Association for the Advancement of Science (AAAS)

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