Embryo-Engineered Nonhuman Primate Models: Progress and Gap to Translational Medicine-Reference-Cited by-同舟云学术

Embryo-Engineered Nonhuman Primate Models: Progress and Gap to Translational Medicine

Published:2021-08-21 Issue: Volume:2021 Page:1-13
ISSN:2639-5274
Container-title:Research
language:en
Short-container-title:Research

Author:

Huang Mei¹²,Yang Jiao¹²,Li Peng¹²,Chen Yongchang¹²^ORCID

Affiliation:

1. Yunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming 650500, China

2. State Key Laboratory of Primate Biomedical Research, Kunming 650500, China

Abstract

Animal models of human diseases are vital in better understanding the mechanism of pathogenesis and essential for evaluating and validating potential therapeutic interventions. As close relatives of humans, nonhuman primates (NHPs) play an increasingly indispensable role in advancing translational medicine research. In this review, we summarized the progress of NHP models generated by embryo engineering, analyzed their unique advantages in mimicking clinical patients, and discussed the remaining gap between basic research of NHP models to translational medicine.

Funder

Major Basic Research Project of Science and Technology of Yunnan

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Link

http://downloads.spj.sciencemag.org/research/2021/9898769.pdf

Reference102 articles.

1. Biological implications and limitations of a cynomolgus monkey with naturally occurring Parkinson’s disease

2. Macaca radiata (bonnet monkey): a spontaneous model of nonalcoholic fatty liver disease

3. Animal Models of PTSD: A Critical Review