Interaction of Diet/Lifestyle Intervention and TCF7L2 Genotype on Glycemic Control and Adiposity among Overweight or Obese Adults: Big Data from Seven Randomized Controlled Trials Worldwide-Reference-Cited by-同舟云学术

Interaction of Diet/Lifestyle Intervention and TCF7L2 Genotype on Glycemic Control and Adiposity among Overweight or Obese Adults: Big Data from Seven Randomized Controlled Trials Worldwide

Published:2021-11-03 Issue: Volume:2021 Page:1-10
ISSN:2765-8783
Container-title:Health Data Science
language:en
Short-container-title:Health Data Science

Author:

Huang Tao¹²³⁴,Zhuang Zhenhuang¹,Heianza Yoriko⁵,Sun Dianjianyi⁵,Ma Wenjie⁶,Wang Wenxiu¹,Gao Meng¹,Fang Zhe¹,Ros Emilio⁷⁸^ORCID,Del Gobbo Liana C.⁹,Salas-Salvadó Jordi⁸¹⁰^ORCID,Martínez-González Miguel A.⁶⁸¹¹^ORCID,Polak Jan¹²,Laakso Markku¹³^ORCID,Astrup Arne¹⁴,Langin Dominique¹⁵,Hager Jorg¹⁶,Hul Gabby¹⁷^ORCID,Hansen Torben¹⁸,Pedersen Oluf¹⁸,Oppert Jean-Michel¹⁹,Saris Wim H. M.¹⁷,Arner Peter²⁰,Cofán Montserrat⁷⁸,Rajaram Sujatha²¹^ORCID,Tuomilehto Jaakko²²²³²⁴,Lindström Jaana²²,de Mello Vanessa D.²⁵^ORCID,Stancacova Alena¹³,Uusitupa Matti²⁵,Svendstrup Mathilde¹⁸²⁶,Sørensen Thorkild I. A.¹⁸²⁷^ORCID,Gardner Christopher D.⁹^ORCID,Sabaté Joan²¹^ORCID,Corella Dolores⁸²⁸,Martinez J. Alfredo⁸²⁹,Qi Lu⁵⁶

Affiliation:

1. Department of Epidemiology & Biostatistics, School of Public Health, Peking University, China

2. Department of Global Health, School of Public Health, Peking University, China

3. Key Laboratory of Molecular Cardiovascular Sciences Ministry of Education, China

4. Global Health Institute Peking University, China

5. Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA

6. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA

7. Department of Endocrinology & Nutrition, Institut d’Investigacions Biomèdiques August Pi Sunyer, Hospital Clínic, Barcelona, Spain

8. CIBER Fisiopatologia de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III (ISCIII), Madrid, Spain

9. Stanford Prevention Research Center, Stanford University, Stanford CA, USA

10. Human Nutrition Unit, Faculty of Medicine and Health Sciences, Pere Virgili Health Research Institute, Rovira i Virgili University, Reus, Spain

11. University of Navarra, Department of Preventive Medicine and Public Health, Medical School & IDISNA, Pamplona, Spain

12. Department for the Study of Obesity and Diabetes, Third Faculty of Medicine, Charles University, Prague, Czech Republic

13. Department of Medicine, University of Eastern Finland, Kuopio, Finland

14. University of Copenhagen, Department of Nutrition, Exercise and Sports, Faculty of Science, Copenhagen, Denmark

15. Institut National de la Santé et de la Recherche Médicale (Inserm), UMR1048, Institute of Metabolic and Cardiovascular Diseases, University of Toulouse and Paul Sabatier University, Toulouse, France

16. Nestlé Institute of Health Sciences, Lausanne, Switzerland

17. Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre +, Maastricht, Netherlands

18. Section of Metabolic Genetics, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

19. Sorbonne Université, Institute of Cardiometabolism and Nutrition (ICAN), Department of Nutrition, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France

20. Department of Medicine, Unit for Endocrinology and Diabetes, Karolinska University Hospital, Stockholm, Sweden

21. School of Public Health, Loma Linda University, Loma Linda, CA, USA

22. Department of Chronic Disease Prevention, Finnish National Institute for Health and Welfare, Helsinki, Finland

23. Department of Public Health, University of Helsinki, Helsinki, Finland

24. Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia

25. Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland

26. Danish Diabetes Academy Odense, Denmark

27. Department of Public Health, Section of Epidemiology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark

28. Department of Preventive Medicine, University of Valencia, Valencia, Spain

29. Department of Nutrition Food Science and Physiology, University of Navarra, IDISNA, Pamplona and IMDEA, Madrid, Spain

Abstract

Objective. The strongest locus which associated with type 2 diabetes (T2D) by the common variant rs7903146 is the transcription factor 7-like 2 gene (TCF7L2). We aimed to quantify the interaction of diet/lifestyle interventions and the genetic effect of TCF7L2 rs7903146 on glycemic traits, body weight, or waist circumference in overweight or obese adults in several randomized controlled trials (RCTs). Methods. From October 2016 to May 2018, a large collaborative analysis was performed by pooling individual-participant data from 7 RCTs. These RCTs reported changes in glycemic control and adiposity of the variant rs7903146 after dietary/lifestyle-related interventions in overweight or obese adults. Gene treatment interaction models which used the genetic effect encoded by the allele dose and common covariates were applicable to individual participant data in all studies. Results. In the joint analysis, a total of 7 eligible RCTs were included (n=4,114). Importantly, we observed a significant effect modification of diet/lifestyle-related interventions on the TCF7L2 variant rs7903146 and changes in fasting glucose. Compared with the control group, diet/lifestyle interventions were related to lower fasting glucose by -3.06 (95% CI, -5.77 to -0.36) mg/dL (test for heterogeneity and overall effect: I2=45.1%, p<0.05; z=2.20, p=0.028) per one copy of the TCF7L2 T risk allele. Furthermore, regardless of genetic risk, diet/lifestyle interventions were associated with lower waist circumference. However, there was no significant change for diet/lifestyle interventions in other glycemic control and adiposity traits per one copy of TCF7L2 risk allele. Conclusions. Our findings suggest that carrying the TCF7L2 T risk allele may have a modestly greater benefit for specific diet/lifestyle interventions to improve the control of fasting glucose in overweight or obese adults.

Funder

European Community

Publisher

American Association for the Advancement of Science (AAAS)

Link

http://downloads.spj.sciencemag.org/hds/2021/9897048.pdf

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