Affiliation:
1. MM College of Pharmacy,
Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala, Haryana 133207, India.
2. Lal Chand Mal College of Education, Jhansa, Kurukshetra, Haryana 136130, India.
3. Department of Biosciences, Saveetha School of Engineering,
Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu 602105, India.
Abstract
Background:
Renal calculi, commonly known as kidney stones, is a prevalent urological condition that affects a substantial portion of the population worldwide. The formation of kidney stones is a complex process influenced by various factors, including diet, fluid intake, genetics, and metabolic abnormalities. The pathogenesis of renal calculi involves a complex interplay of multiple factors, including supersaturation of urine with stone-forming constituents, urinary supersaturation, crystallization, and aggregation.
Objective:
This review aims to provide an overview of the present understanding of renal calculi, their pathophysiology, diagnostic approaches, and available treatment modalities.
Methods:
This review discusses the different types of kidney stones, such as calcium oxalate, calcium phosphate, uric acid, and struvite stones, and explores their formation mechanisms and associated risk factors. The management of renal calculi relies on stone characteristics, patient symptoms, stone size, and location. Furthermore, counseling and education regarding lifestyle modifications and risk factor management are essential for long-term management.
Conclusion:
Accurate diagnosis and appropriate management based on stone characteristics and patient symptoms are essential for successful outcomes. Preventive strategies to reduce stone recurrence are vital for long-term management and patient well-being. However, further research is needed to refine diagnostic techniques, improve treatment options, and enhance the understanding of the underlying pathophysiology of renal calculi.
Publisher
American Association for the Advancement of Science (AAAS)