Natural Flavonoid-Derived Enzyme Mimics DHKNase Balance the Two-Edged Reactive Oxygen Species Function for Wound Healing and Inflammatory Bowel Disease Therapy-Reference-Cited by-同舟云学术

Natural Flavonoid-Derived Enzyme Mimics DHKNase Balance the Two-Edged Reactive Oxygen Species Function for Wound Healing and Inflammatory Bowel Disease Therapy

Published:2024-01 Issue: Volume:7 Page:
ISSN:2639-5274
Container-title:Research
language:en
Short-container-title:Research

Author:

Feng Guangfu¹,Zhang Huaizu¹^ORCID,Liu Huipeng¹,Zhang Xiaoyan²,Jiang Hongmei¹,Liao Sijie¹,Luo Xingyu³,Yao Hao⁴,Xiang Bo¹,Liu Shiyu¹,Zhang Jiali¹,Zhang Jiaheng⁵,Fang Jun¹^ORCID

Affiliation:

1. School of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan 410128, P.R. China.

2. College of Life Science, Shihezi University, Shihezi, Xinjiang 832003, P.R. China.

3. School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, P.R. China.

4. Changsha IMADEK Intelligent Technology Co. Ltd., Changsha, Hunan 410081, P.R. China.

5. College of Chemistry, Food Laboratory of Zhongyuan, Flavour Science Research Center of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China.

Abstract

Rational regulation of reactive oxygen species (ROS) plays a vital importance in maintaining homeostasis of living biological systems. For ROS-related pathologies, chemotherapy technology derived from metal nanomaterials currently occupies a pivotal position. However, they suffer from inherent issues such as complicated synthesis, batch-to-batch variability, high cost, and potential biological toxicity caused by metal elements. Here, we reported for the first time that dual-action 3,5-dihydroxy-1-ketonaphthalene-structured small-molecule enzyme imitator (DHKNase) exhibited 2-edged ROS regulation, catering to the execution of physiology-beneficial ROS destiny among diverse pathologies in living systems. Based on this, DHKNase is validated to enable remarkable therapeutic effects in 2 classic disease models, including the pathogen-infected wound-healing model and the dextran sulfate sodium (DSS)-caused inflammatory bowel disease (IBD). This work provides a guiding landmark for developing novel natural small-molecule enzyme imitator and significantly expands their application potential in the biomedical field.

Funder

Science and Technology Innovation Program of Hunan Province

National Natural Science Foundation of China

Scientific Research Foundation of Hunan Provincial Education Department

Hunan Provincial Science and Technology Department

Opening Foundation of the State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University

Double first-class construction project of Hunan Agricultural University

National Key Research and Development Program

Publisher

American Association for the Advancement of Science (AAAS)

Link

https://spj.science.org/doi/pdf/10.34133/research.0464

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