Impact of statin use on perioperative bleeding in patients with benign prostatic hyperplasia who underwent monopolar TURP

Abstract

Objective: We aimed to evaluate the effect of statin use on bleeding complications in benign prostate hyperplasia (BPH) patients who underwent transurethral resection of the prostate (TURP).Material and Methods: This prospective case-control study included patients with benign prostatic hyperplasia (BPH) who underwent TURP surgery. Seventy-six patients were included (30 statin users and 74 statin non-users). Data including patient age, preoperative laboratory values(complete blood count, prostate-specific antigen (PSA) levels, prostate volume, international normalized ratio (INR), activated partial thromboplastin time (aPTT)), intraoperative characteristics(amount of resected prostate tissue, blood transfusion, duration of surgery, duration of urinary catheterization) and postoperative features(serum complete blood count, and length of hospital stay)were collected. Patients who underwent TURP with or without statin use were compared with hematocrit and bleeding complications. Results: There was no difference between the groups regarding the degree of reduction in hematocrit and platelet count. In both groups, postoperative hematocrit and platelet counts were significantly lower than preoperative values. There was no significant difference between the groups regarding age, PSA, prostate volume, histopathological diagnosis, transurethral resection (TUR) volume, INR, PT, aPTT, number of red blood cell (RBC) units transfused, duration of surgery, irrigation time, hematocrit, and platelet count. TUR volume, frequency of anticoagulant use, duration, and length of hospital stay were statistically higher in the statin user groupConclusion: Our results showed that statin use did not impact bleeding in patients with BPH who underwent TURP. Considering the widespread use of statins, during surgery the effects of bleeding, we need more information on further studies to light.