Effectıveness of Curcumın on Tracheal Anastomosıs Created in the Rat Model

Abstract

Objective: We aimed to investigate the effect of curcumin on tracheal wound healing in the anastomosis model following tracheal incision in rats. Methods: Twenty-one healthy male Wistar Albino rats were included in the study. A horizontal incision was made between the 2nd-3th rings of the rat trachea and damage was created in the inner tracheal mucosa. Tracheal incision area was sutured and anastomosis was performed. Rats were divided into three groups. Ringer was given to the first group, corticosteroids to the 2nd group, and curcumin to the 3rd group for 28 days. The rats were sacrificed on the 28th day and the tracheal anastomosis line samples were sent for histological examination. Wound healing parameters, tracheal lumen width, wall thickness, and stenosis index were evaluated. Results: Statistically significant difference was detected in tracheal lumen width and wall thickness in the curcumin group (p<0.05). Statistically significant differences were observed in the curcumin group in parameters of inflammation, collagen production and fibrosis. (p<0.05). Conclusion: It is important to prevent the formation of tracheal stenosis, which is difficult to treat in clinical practice. Desired results cannot be achieved in the side-effect profile of some medical drugs used in this regard. We found the positive effect of Curcumin in the prevention of stenosis following tracheal injury.