Particle Deposition in Arteries Ex Vivo: Effects of Pressure, Flow, and Waveform-Reference-Cited by-同舟云学术

Particle Deposition in Arteries Ex Vivo: Effects of Pressure, Flow, and Waveform

Published:2003-06-01 Issue:3 Volume:125 Page:389-394
ISSN:0148-0731
Container-title:Journal of Biomechanical Engineering
language:en
Short-container-title:

Author:

Chesler Naomi C.¹,Enyinna Omyekachi C.²

Affiliation:

1. Department of Mechanical Engineering, University of Vermont, Burlington, VT 05405-0156

2. Biomedical Engineering Program, University of Vermont, Burlington, VT 05405-0156

Abstract

The goal of this study was to quantify the effect of hemodynamic pressure, flow and waveform perturbations on the deposition of protein-sized particles in porcine carotid arteries ex vivo. An ex vivo perfusion system was used to control the pressure and flow environment for excised arterial tissue. Confocal laser microscopy images revealed that 200 nm particles were deposited intimally and that more spheres were evident along vessels perfused under oscillatory waveform conditions than all others. Under all pressure, flow and waveform conditions, particles were excluded from the media and adventitia of the vessel wall. The steady flow data support the use of Darcy’s Law with pressure-dependent hydraulic permeability to model arterial tissue.

Publisher

ASME International

Subject

Physiology (medical),Biomedical Engineering

Link

http://asmedigitalcollection.asme.org/biomechanical/article-pdf/125/3/389/5768466/389_1.pdf

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