Two-Dimensional Optimization of a Stent for an Aneurysm-Reference-Cited by-同舟云学术

Two-Dimensional Optimization of a Stent for an Aneurysm

Published:2010-06-01 Issue:2 Volume:4 Page:
ISSN:1932-6181
Container-title:Journal of Medical Devices
language:en
Short-container-title:

Author:

Srinivas K.¹,Townsend S.²,Lee C. J.²,Nakayama T.³,Ohta M.³,Obayashi S.³,Yamaguchi T.⁴

Affiliation:

1. School of Aerospace, Mechanical and Mechatronic Engineering, University of Sydney, New South Wales 2006, Australia; Institute of Fluid Science, Tohoku University, 980-8577 Japan

2. School of Aerospace, Mechanical and Mechatronic Engineering, University of Sydney, New South Wales 2006, Australia

3. Institute of Fluid Science, Tohoku University, 980-8577 Japan

4. Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku University, 980-8577 Japan

Abstract

This work attempts to optimize stents that are implanted at the neck of coronary or cerebral aneurysms to effect a flow diversion. A two-dimensional version of the stent, which is a series of struts and gaps placed at the neck, is considered as the first step. Optimization is carried out based on the principles of exploration of design space using reductions in velocity and vorticity in the aneurysm dome as the objective functions. Latin hypercube sampling first develops 30–60 samples of a strut-gap arrangement. Flow past an aneurysm with each of these samples is computed using the commercial software FLUENT and the objective functions evaluated. This is followed by a Kriging procedure that identifies the nondominated solutions to the system, which are the optimized candidates. Three different cases of stents with rectangular or circular struts are considered. It is found that placing struts in the proximal region of the neck gives the best flow diversion.

Publisher

ASME International

Subject

Biomedical Engineering,Medicine (miscellaneous)

Link

http://asmedigitalcollection.asme.org/medicaldevices/article-pdf/doi/10.1115/1.4001861/5928713/021003_1.pdf

Reference19 articles.

1. Studies on Design Optimization of Coronary Stents;Srinivas;ASME J. Med. Devices

2. Hemodynamics of Cerebral Aneurysms;Sforza;Annu. Rev. Fluid Mech.

3. The Biomechanics of Arterial Aneurysms;Lasheras;Annu. Rev. Fluid Mech.

4. Characterization of Flow Reduction Properties in an Aneurysm Due to a Stent;Hirabayashi;Phys. Rev. E

5. Comparison of Two Stents in Modifying Cerebral Aneurysm Hemodynamics;Kim;Annals Bioengineering

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