Linear Poroelastic Cancellous Bone Anisotropy: Trabecular Solid Elastic and Fluid Transport Properties
Author:
Kohles Sean S.12, Roberts Julie B.3
Affiliation:
1. Kohles Bioengineering, 1731 SE 37th Ave, Portland, OR 97214-5135 2. Department of Mechanical Engineering, Oregon State University, Corvallis, OR 3. TEI Biosciences, Inc., 7 Elkins St, Boston, MA 02127
Abstract
The mechanical performance of cancellous bone is characterized using experiments which apply linear poroelasticity theory. It is hypothesized that the anisotropic organization of the solid and pore volumes of cancellous bone can be physically characterized separately (no deformable boundary interactive effects) within the same bone sample. Due to its spongy construction, the in vivo mechanical function of cancellous or trabecular bone is dependent upon fluid and solid materials which may interact in a hydraulic, convective fashion during functional loading. This project provides insight into the organization of the tissue, i.e., the trabecular connectivity, by defining the separate nature of this biphasic performance. Previous fluid flow experiments [Kohles et al., 2001, Journal of Biomechanics, 34(11), pp. 1197–1202] describe the pore space via orthotropic permeability. Ultrasonic wave propagation through the trabecular network is used to describe the solid component via orthotropic elastic moduli and material stiffness coefficients. The linear poroelastic nature of the tissue is further described by relating transport (fluid flow) and elasticity (trabecular load transmission) during regression analysis. In addition, an empirical relationship between permeability and porosity is applied to the collected data. Mean parameters in the superior-inferior (SI) orientation of cubic samples n=20 harvested from a single bovine distal femur were the largest p<0.05 in comparison to medial-lateral (ML) and anterior-posterior (AP) orientations: Apparent elastic modulus (2,139 MPa), permeability (4.65×10−10 m2), and material stiffness coefficient (13.6 GPa). A negative correlation between permeability as a predictor of structural elastic modulus supported a parametric relationship in the ML R2=0.4793, AP R2=0.3018, and SI R2=0.6445 directions p<0.05.
Publisher
ASME International
Subject
Physiology (medical),Biomedical Engineering
Reference52 articles.
1. Carter, D. R. and Hayes, W. C., 1977, “The Compressive Behavior of Bone as a Two-Phase Porous Structure,” J. Bone Jt. Surg., 59A, pp. 954–962. 2. Simkin, P. A., Houglum, S. J., and Pickerell, C. C., 1985a, “Compliance and Viscoelasticity of Canine Shoulders Loaded in vitro,” J. Biomech., 18, p. 735–743. 3. Keaveny, T. M., and Hayes, W. C., 1993, “A 20-Year Perspective on the Mechanical Properties of Trabecular Bone,” ASME J. Biomech. Eng., 115, pp. 534–542. 4. Ochoa, J. A., Sanders, A. P., Kiesler, T. W., Heck, D. A., Toombs, J. P., Brandt, K. D., and Hillberry, B. M., 1977, “In vivo Observations of Hydraulic Stiffening in the Canine Femoral Head,” ASME J. Biomech. Eng., 119, pp 103–108. 5. Arramon, Y. P., and Cowin, S. C., 1997, “Hydraulic Stiffening of Cancellous Bone,” Forma, 12, pp. 209–221.
Cited by
46 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|