Evaluation of Meniscal Mechanics and Proteoglycan Content in a Modified Anterior Cruciate Ligament Transection Model-Reference-Cited by-同舟云学术

Evaluation of Meniscal Mechanics and Proteoglycan Content in a Modified Anterior Cruciate Ligament Transection Model

Published:2014-05-12 Issue:7 Volume:136 Page:
ISSN:0148-0731
Container-title:Journal of Biomechanical Engineering
language:en
Short-container-title:

Author:

Fischenich Kristine M.¹,Coatney Garrett A.¹,Haverkamp John H.¹,Button Keith D.²,DeCamp Charlie³,Haut Roger C.⁴,Haut Donahue Tammy L.¹

Affiliation:

1. Department of Mechanical Engineering, Colorado State University, Campus Delivery 1374, Fort Collins, CO 80523 e-mail:

2. Orthopaedic Biomechanics Laboratories, College of Osteopathic Medicine, Michigan State University, East Fee Hall 965 Fee Road, Room A-439, East Lansing, MI 48824

3. Small Animal Clinical Sciences, College of Veterinary, Michigan State University, 784 Wilson Road, Room G-100, East Lansing, MI 48824 e-mail:

4. Orthopaedic Biomechanics Laboratories, College of Osteopathic Medicine, Michigan State University, East Fee Hall 965 Fee Road, Room A-439, East Lansing, MI 48824 e-mail:

Abstract

Post-traumatic osteoarthritis (PTOA) develops as a result of traumatic loading that causes tears of the soft tissues in the knee. A modified transection model, where the anterior cruciate ligament (ACL) and both menisci were transected, was used on skeletally mature Flemish Giant rabbits. Gross morphological assessments, elastic moduli, and glycosaminoglycan (GAG) coverage of the menisci were determined to quantify the amount of tissue damage 12 weeks post injury. This study is one of the first to monitor meniscal changes after inducing combined meniscal and ACL transections. A decrease in elastic moduli as well as a decrease in GAG coverage was seen.

Publisher

ASME International

Subject

Physiology (medical),Biomedical Engineering

Link

http://asmedigitalcollection.asme.org/biomechanical/article-pdf/doi/10.1115/1.4027468/6090954/bio_136_07_071001.pdf

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