Low Background, Pulsatile, In Vitro Flow Circuit for Modeling Coronary Implant Thrombosis
Author:
Kolandaivelu Kumaran1, Edelman Elazer R.23
Affiliation:
1. Harvard-MIT Division of Health Science and Technology, Massachusetts Institute of Technology, 77 Massachusetts Ave. Bldg 16-343, Cambridge, MA 02139 2. Harvard-MIT Division of Health Science and Technology, Massachusetts Institute of Technology, 77 Massachusetts Ave. Bld 16-343, Cambridge, MA 02139 3. Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis St., Boston, MA 02115
Abstract
We have developed an in vitro method for creating pulsatile flows to mimic coronary type flow patterns on a beat-to-beat basis. The flow is created by accelerating fluid loops about an axis, inducing relative wall motion. Using this technique, a variety of oscillating flow patterns can be generated and modulated. Such flow generation offers the potential to monitor sensitive, flow-dependent, biological parameters like thrombosis while minimizing background disturbances from pump action and circuit effects. We examined this potential by measuring the loop occlusion time for loops stented with stainless steel 7-9 NIR® stents and stentless control loops.
Publisher
ASME International
Subject
Physiology (medical),Biomedical Engineering
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