Effects of 3,5,3′-Triiodothyroacetic Acid, Nanoencapsulated or Not, on Intact and Atrophic Skin in Rats-Reference-Cited by-同舟云学术

Effects of 3,5,3′-Triiodothyroacetic Acid, Nanoencapsulated or Not, on Intact and Atrophic Skin in Rats

Published:2014-08-01 Issue:3 Volume:5 Page:
ISSN:1949-2944
Container-title:Journal of Nanotechnology in Engineering and Medicine
language:en
Short-container-title:

Author:

Trevizan Pera Daniele¹,Freitas Planello Jéssica²,Cancino Juliana³,Polikarpov Igor³,Zucolotto Valtencir³,Retto da Silva de Avó Lucimar²,Maria Ramos Germano Carla²,Gusmão Melo Débora²

Affiliation:

1. Postgraduate Program in Biotechnology (PPGBiotec), Federal University of São Carlos (UFSCar), São Carlos, São Paulo CEP 13565-905, Brazil e-mail:

2. Department of Medicine (DMed), Federal University of São Carlos (UFSCar), São Carlos, São Paulo CEP 13565-905, Brazil e-mail:

3. Physics Institute of São Carlos (IFSC), University of São Paulo (USP), São Carlos, São Paulo CEP 13566-590, Brazil e-mail:

Abstract

We aimed to investigate 3,5,3′-triiodothyroacetic acid (TRIAC) effects on intact and atrophic skin induced by glucocorticoids (GCs) in rats and the effects induced by nanoencapsulation. The effects of TRIAC and nanoencapsulated TRIAC were evaluated on intact and atrophic skin in TRIAC experiment and nanoencapsulated TRIAC experiment, respectively. Both experiments had two phases: phase I, cutaneous atrophy was induced; phase II, TRIAC or nanoencapsulated TRIAC was administrated. Our results showed that topical use of TRIAC with or without nanoencapsulation was able to reverse cutaneous atrophy. Nanoencapsulated TRIAC showed less systemic changes than TRIAC; therefore, it is possibly a safer drug for topical administration.

Publisher

ASME International

Subject

Electrical and Electronic Engineering,General Materials Science,General Medicine

Link

http://asmedigitalcollection.asme.org/nanoengineeringmedical/article-pdf/doi/10.1115/1.4028695/6281154/nano_005_03_031001.pdf

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