Measurement and Modeling of Transport Across the Blood–Brain Barrier

Author:

Fan Hanwen1,Cai Qi1,Qin Zhenpeng2345ORCID

Affiliation:

1. Department of Mechanical Engineering, The University of Texas at Dallas , Richardson, TX 75080

2. Department of Mechanical Engineering, The University of Texas at Dallas , Richardson, TX 75080 ; , Richardson, TX 75080 ; , Dallas, TX 75390 ; , Richardson, TX 75080

3. Department of Bioengineering, The University of Texas at Dallas , Richardson, TX 75080 ; , Richardson, TX 75080 ; , Dallas, TX 75390 ; , Richardson, TX 75080

4. Department of Surgery, University of Texas Southwestern Medical Center , Richardson, TX 75080 ; , Richardson, TX 75080 ; , Dallas, TX 75390 ; , Richardson, TX 75080

5. Center for Advanced Pain Studies, The University of Texas at Dallas , Richardson, TX 75080 ; , Richardson, TX 75080 ; , Dallas, TX 75390 ; , Richardson, TX 75080

Abstract

Abstract The blood–brain barrier (BBB) is a dynamic regulatory barrier at the interface of blood circulation and the brain parenchyma, which plays a critical role in protecting homeostasis in the central nervous system. However, it also significantly impedes drug delivery to the brain. Understanding the transport across BBB and brain distribution will facilitate the prediction of drug delivery efficiency and the development of new therapies. To date, various methods and models have been developed to study drug transport at the BBB interface, including in vivo brain uptake measurement methods, in vitro BBB models, and mathematic brain vascular models. Since the in vitro BBB models have been extensively reviewed elsewhere, we provide a comprehensive summary of the brain transport mechanisms and the currently available in vivo methods and mathematic models in studying the molecule delivery process at the BBB interface. In particular, we reviewed the emerging in vivo imaging techniques in observing drug transport across the BBB. We discussed the advantages and disadvantages associated with each model to serve as a guide for model selection in studying drug transport across the BBB. In summary, we envision future directions to improve the accuracy of mathematical models, establish noninvasive in vivo measurement techniques, and bridge the preclinical studies with clinical translation by taking the altered BBB physiological conditions into consideration. We believe these are critical in guiding new drug development and precise drug administration in brain disease treatment.

Funder

Cancer Prevention and Research Institute of Texas

National Institute of General Medical Sciences

National Institutes of Health

Publisher

ASME International

Subject

Physiology (medical),Biomedical Engineering

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3