Short-Pulse Laser-Based System for Detection of Tumors: Administration of Gold Nanoparticles Enhances Contrast-Reference-Cited by-同舟云学术

Short-Pulse Laser-Based System for Detection of Tumors: Administration of Gold Nanoparticles Enhances Contrast

Published:2012-05-01 Issue:2 Volume:3 Page:
ISSN:1949-2944
Container-title:Journal of Nanotechnology in Engineering and Medicine
language:en
Short-container-title:

Author:

Sajjadi A. Y.,Suratkar A.,Mitra K.¹,Grace M. S.²

Affiliation:

1. Department of Mechanical & Aerospace Engineering, Florida Institute of Technology, Melbourne, FL 32901

2. Department of Biological Sciences, Florida Institute of Technology, Melbourne, FL 32901

Abstract

The objective of this paper is to demonstrate the use of gold nanoparticles, which accumulate in tumors due to the leakiness of tumor vasculature, as contrast agents for enhanced imaging in a time-resolved optical tomography system using short-pulse lasers for skin cancer detection in mouse model. It is found that intravenously administrated spherical gold nanoparticles broadened the temporal profile of reflected optical signals and enhanced the contrast between surrounding normal tissue and tumors. These results show that gold nanoparticles tuned to the wavelength of the laser can enhance the resolution and precision of laser-based cancer detection system.

Publisher

ASME International

Subject

Electrical and Electronic Engineering,General Materials Science,General Medicine

Link

http://asmedigitalcollection.asme.org/nanoengineeringmedical/article-pdf/doi/10.1115/1.4007245/5937447/nano_3_2_021002.pdf

Reference43 articles.

1. Scanning Near-Field Optical Microscopy With Aperture Probes: Fundamentals and Applications;J. Chem. Phys.,2000

2. Optical Coherence Tomography (OCT): A Review;IEEE J. Sel. Topics Quantum Electron.,1999

3. Imaging the Body With Diffuse Optical Tomography;IEEE Signal Process. Mag.,2001

4. Methods for Imaging the Structure and Function of Living Tissues and Cells: 2. Fluorescence Lifetime Imaging;J. Pathol.,2000

5. The Use of Confocal Microscopy in the Investigation of Cell Structure and Function in the Heart, Vascular Endothelium and Smooth Muscle Cells;Mol. Cell. Biochem.,1997

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