Mechanism of Incomplete Mitral Leaflet Coaptation—Interaction of Chordal Restraint and Changes in Mitral Leaflet Coaptation Geometry-Reference-Cited by-同舟云学术

Mechanism of Incomplete Mitral Leaflet Coaptation—Interaction of Chordal Restraint and Changes in Mitral Leaflet Coaptation Geometry

Published:2002-09-30 Issue:5 Volume:124 Page:596-608
ISSN:0148-0731
Container-title:Journal of Biomechanical Engineering
language:en
Short-container-title:

Author:

Nielsen Sten Lyager¹,Nygaard Hans²,Mandrup Lars³,Fontaine Arnold A.⁴,Hasenkam J. Michael⁵,He Shengqui⁶,Yoganathan Ajit P.⁶

Affiliation:

1. Department of Cardiothoracic and Vascular Surgery and Institute of Experimental Clinical Research, Skejby Sygehus, Aarhus University Hospital, Aarhus, Denmark

2. Department of Cardiothoracic and Vascular Surgery and Institute of Experimental Clinical Research, Skejby Sygehus, Aarhus University Hospital, and Engineering College of Aarhus, Aarhus, Denmark

3. Engineering College of Aarhus, Aarhus, Denmark

4. Applied Research Laboratory, Penn State University, State College, PA

5. Department of Cardiothoracic and Vascular Surgery and Institute of Experimental Clinical Research, Skijby Sygehus, Aarhus University Hospital, Aarhus, Denmark

6. Institute for Bioscience and Bioengineering, Chemical Engineering Department, Georgia Institute of Technology, Atlanta, GA

Abstract

Clinically observed incomplete mitral leaflet coaptation was reproduced in vitro by altering the balance of the chordal tethering and chordal coapting force components. Mitral leaflet coaptation geometry was distorted by changes of the spatial relations between the papillary muscles and the mitral valve as well as hemodynamics. Mitral leaflet malalignment was accentuated by a redistribution of the chordal tethering and coapting force components. For the overall assessment of systolic mitral leaflet configuration in functional mitral regurgitation it is important to consider the interaction between chordal restraint and an altered mitral leaflet coaptation geometry.

Publisher

ASME International

Subject

Physiology (medical),Biomedical Engineering

Link

http://asmedigitalcollection.asme.org/biomechanical/article-pdf/124/5/596/5526277/596_1.pdf

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