A Flow System for the Study of Shear Forces Upon Cultured Endothelial Cells-Reference-Cited by-同舟云学术

A Flow System for the Study of Shear Forces Upon Cultured Endothelial Cells

Published:1986-11-01 Issue:4 Volume:108 Page:338-341
ISSN:0148-0731
Container-title:Journal of Biomechanical Engineering
language:en
Short-container-title:

Author:

Koslow A. R.¹,Stromberg R. R.¹,Friedman L. I.¹,Lutz R. J.²,Hilbert S. L.³,Schuster P.³

Affiliation:

1. American Red Cross Biomedical Research and Development Laboratories, Bethesda, Md. 20814

2. Division of Research Services, National Institutes of Health, Bethesda, Md. 20205

3. Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Md. 20857

Abstract

A parallel plate chamber in a flow system has been designed to study the effects of fluid shear stresses on cells. The system was applied to the study of cultured endothelial cells grown on cover slips which were accommodated in recessed wells in the base plate. Dye injection studies in the chamber indicated laminar flow over the cells. Shear rates measured over the cover slips by an electrochemical technique were found to be linear with flow rate. Laser doppler anemometry showed parabolic profiles between the plates. Endothelial cells subjected to flow showed a correlation between the time required for orientation and the magnitude of the shear stress.

Publisher

ASME International

Subject

Physiology (medical),Biomedical Engineering

Link

http://asmedigitalcollection.asme.org/biomechanical/article-pdf/108/4/338/5766049/338_1.pdf

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