A Vascular Model for Heat Transfer in an Isolated Pig Kidney During Water Bath Heating
Affiliation:
1. School of Mechanical Engineering, Purdue University, USA 2. School of Mechanical Engineering, Department of Biomedical Engineering, Purdue University, USA 3. School of Life Science and Technology, Shanghai Jiao Tong University, People’s Republic of China
Abstract
Isolated pig kidney has been widely used as a perfused organ phantom in the studies of hyperthermia treatments, as blood perfusion plays an essential role in thermoregulation of living tissues. In this research, a vascular model was built to describe heat transfer in the kidney phantom during water bath heating. The model accounts for conjugate heat transfer between the paired artery and vein, and their surrounding tissue in the renal medulla. Tissue temperature distribution in the cortex was predicted using the Pennes bioheat transfer equation. An analytical solution was obtained and validated experimentally for predicting the steady state temperature distribution in the pig kidney when its surface kept at a uniform constant temperature. Results showed that local perfusion rate significantly affected tissue temperature distributions. Since blood flow is the driving force of tissue temperature oscillations during hyperthermia, the newly developed vascular model provides a useful tool for hyperthermia treatment optimization using the kidney phantom model.
Publisher
ASME International
Subject
Mechanical Engineering,Mechanics of Materials,Condensed Matter Physics,General Materials Science
Reference18 articles.
1. Dyce, K. M., Sack, W. O., and Wensing, C. J. G., 1996, Textbook of Veterinary Anatomy, W. B. Saunders Company, Philadelphia, PA. 2. Holmes, K. R., Ryan, W., Weinstein, P., and Chen, M. M., 1984, “A Fixation Technique for Organs to be Used as Perfused Tissue Phantoms in Bioheat Transfer Studies,” ASME Adv. in Bioeng., 11, pp. 9–10. 3. Zaerr, J., Roemer, R. B., and Hynynen, K., 1990, “Computer-Controlled Dynamic Phantom for Ultrasound Hyperthermia Studies,” IEEE Trans. Biomed. Eng., 37(11), pp. 1115–1120. 4. Xu, L. X., 1999, “New Developments in Bioheat and Mass Transfer,” Ann. Rev. Heat Trans., C. L. Tien, ed., Begell House, Chap. 1. 5. Brown, S. L., Li, X. L., Pai, H. H., Worthington, A. E., Hill, R. P., and Hunt, J. W., 1992, “Observations of Thermal Gradients in Perfused Tissues During Water Bath Heating,” Int. J. Hyperthermia, 8(2), pp. 275–287.
Cited by
12 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|