Computational Analyses of Mechanically Induced Collagen Fiber Remodeling in the Aortic Heart Valve
Author:
Driessen Niels J. B.1, Boerboom Ralf A.1, Huyghe Jacques M.1, Bouten Carlijn V. C.1, Baaijens Frank P. T.1
Affiliation:
1. Eindhoven University of Technology, Department of Biomedical Engineering, Laboratory for Biomechanics and Tissue Engineering, PO Box 513, 5600 MB Eindhoven, The Netherlands
Abstract
To optimize the mechanical properties and integrity of tissue-engineered aortic heart valves, it is necessary to gain insight into the effects of mechanical stimuli on the mechanical behavior of the tissue using mathematical models. In this study, a finite-element (FE) model is presented to relate changes in collagen fiber content and orientation to the mechanical loading condition within the engineered construct. We hypothesized that collagen fibers aligned with principal strain directions and that collagen content increased with the fiber stretch. The results indicate that the computed preferred fiber directions run from commissure to commissure and show a strong resemblance to experimental data from native aortic heart valves.
Publisher
ASME International
Subject
Physiology (medical),Biomedical Engineering
Reference46 articles.
1. Schoen, F. J., and Levy, R. J., 1999, “Tissue Heart Valves: Current Challenges and Future Research Perspectives,” J. Biomed. Mater. Res., 47(4), pp. 439–465. 2. Sodian, R., Hoerstrup, S. P., Sperling, J. S., Daebritz, S., Martin, D. P., Moran, A. M., Kim, B. S., Schoen, F. J., Vacanti, J. P., and Mayer, Jr., J. E., 2000, “Early in vivo Experience With Tissue-Engineered Trileaflet Heart Valves,” Circulation, 102(19), pp. III22–III29III22–III29. 3. Hoerstrup, S. P., Sodian, R., Daebritz, S., Wang, J., Bacha, E. A., Martin, D. P., Moran, A. M., Guleserian, K. J., Sperling, J. S., Kaushal, S., Vacanti, J. P., Schoen, F. J., and Mayer, Jr., J. E., 2000, “Functional Living Trileaflet Heart Valves Grown in vitro,” Circulation, 102(19), pp. III44–III49III44–III49. 4. Sodian, R., Hoerstrup, S. P., Sperling, J. S., Daebritz, S., Martin, D. P., Schoen, F. J., Vacanti, J. P., and Mayer, Jr., J. E., 2000, “Tissue Engineering of Heart Valves: in vitro Experiences,” Ann. Thorac. Surg., 70(1), pp. 140–144. 5. Sauren, A. A. H. J., 1981, “The Mechanical Behavior of the Aortic Valve,” Ph.D. thesis, Technische Hogeschool Eindhoven.
Cited by
85 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
|
|