Mechanical Properties of a Reversible, DNA-Crosslinked Polyacrylamide Hydrogel

Author:

Lin David C.1,Yurke Bernard2,Langrana Noshir A.1

Affiliation:

1. Department of Mechanical and Aerospace Engineering, Rutgers, The State University of New Jersey, 98 Brett Road, Piscataway, NJ 08854

2. Bell Laboratories, Lucent Technologies Inc., 600 Mountain Avenue, Murray Hill, NJ 07974

Abstract

Mechanical properties of a polyacrylamide gel with reversible DNA crosslinks are presented. In this system, three DNA strands replace traditional chemical crosslinkers. In contrast to thermoset chemically crosslinked polyacrylamide, the new hydrogel is thermoreversible; crosslink dissociation without the addition of heat is also feasible by introducing a specific removal DNA strand. This hydrogel is characterized by a critical crosslink concentration at which gelation occurs. Below the critical point, a characteristic temperature exists at which a transition in viscosity is observed. Both temperature-dependent viscosity and elastic modulus of the material are functions of crosslink density.

Publisher

ASME International

Subject

Physiology (medical),Biomedical Engineering

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