Studies on the Three-Dimensional Temperature Transients in the Canine Prostate During Transurethral Microwave Thermal Therapy
Author:
Liu Jing1, Zhu Liang2, Xu Lisa X.3
Affiliation:
1. School of Mechanical Engineering, Purdue University, West Lafayette, IN 47907-1288 2. Department of Mechanical Engineering, University of Maryland at Baltimore County, Baltimore, MD 21250 3. School of Mechanical Engineering, Department of Biomedical Engineering, Purdue University, West Lafayette, IN 47907-1288
Abstract
Thermal therapy of benign prostatic hyperplasia requires accurate prediction of the temperature distribution induced by the heating within the prostatic tissue. In this study, the Pennes bioheat transfer equation was used to model the transient heat transfer inside the canine prostate during transurethral microwave thermal therapy. Incorporating the specific absorption rate of microwave energy in tissue, a closed-form analytical solution was obtained. Good agreement was found between the theoretical predictions and in-vivo experimental results. Effects of blood perfusion and the cooling at the urethral wall on the temperature rise were investigated within the prostate during heating. The peak intraprostatic temperatures attained by application of 5, 10, or 15 W microwave power were predicted to be 38°C,41°C, and 44°C. Results from this study will help optimize the thermal dose that can be applied to target tissue during the therapy. [S0148-0731(00)01004-9]
Publisher
ASME International
Subject
Physiology (medical),Biomedical Engineering
Reference32 articles.
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