Analysis of Thermal Injury Process Based on Enzyme Deactivation Mechanisms

Author:

Xu Yunsheng1,Qian Renzhang2

Affiliation:

1. Department of Engineering Mechanics, Tsinghua University, Beijing 100084, China

2. Department of Power Engineering, Huazhong University of Science and Technology, Wuhan 430074, China

Abstract

Based upon the analysis of enzyme-catalyzed reactions occurring in living tissue, a model of thermal injury process is presented in which the fraction of denatured enzyme protein was taken as the indicator of thermal damage degrees. The results from this model describe the dependence of thermal damage on exposure time and temperature elevation.

Publisher

ASME International

Subject

Physiology (medical),Biomedical Engineering

Reference12 articles.

1. Balley, J. E., and Olliss, D. F., 1986, Biochemical Engineering Fundamentals, 2nd ed., McGraw-Hill.

2. Henriques F. C. , 1947, “Studies of Thermal Injury (V), the Predictability and the Significance of Thermally Induced Rate Process Leading to Irreversible Epidermal Injury,” Archives of Pathology, Vol. 43, pp. 489–502.

3. Henriques F. C. , and MoritzA. R., 1947, “Studies of Thermal Injury, (I), The Conduction of Heat to and an Experimental Investigation,” American Journal of Pathology, Vol. 23, pp. 531–549.

4. Laider, K. J., and Bunting, P. S., 1973, The Chemical Kinetics of Enzyme Reactions, Clarendon Press, Oxford, London, p. 430.

5. Moritz A. R. , and HenriquesF. C., 1947, “Studies of Thermal Injury (II), The Relative Importance of Time and Source Temperature in the Causation of Cutaneous Burns,” American Journal of Pathology, Vol. 23, pp. 695–720.

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