Quantitative Evaluation of Blood Damage in a Centrifugal VAD by Computational Fluid Dynamics
Author:
Song Xinwei1, Throckmorton Amy L.2, Wood Houston G.1, Antaki James F.3, Olsen Don B.4
Affiliation:
1. Mechanical and Aerospace Engineering Department, Virginia Artificial Heart Institute, University of Virginia, Charlottesville, VA USA 2. Biomedical Engineering Department, Virginia Artificial Heart Institute, University of Virginia, Charlottesville, VA USA 3. McGowan Center for Artificial Organ Development, University of Pittsburgh, Pittsburgh, PA USA 4. Utah Artificial Heart Institute, Salt Lake City, UT USA
Abstract
This study explores a quantitative evaluation of blood damage that occurs in a continuous flow left ventricular assist device (LVAD) due to fluid stress. Computational fluid dynamics (CFD) analysis is used to track the shear stress history of 388 particle streaklines. The accumulation of shear and exposure time is integrated along the streaklines to evaluate the levels of blood trauma. This analysis, which includes viscous and turbulent stresses, provides a statistical estimate of possible damage to cells flowing through the pump. Since experimental data for hemolysis levels in our LVAD are not available, in vitro normalized index of hemolysis values for clinically available ventricular assist devices were compared to our damage indices. This approach allowed for an order of magnitude comparison between our estimations and experimentally measured hemolysis levels, which resulted in a reasonable correlation. This work ultimately demonstrates that CFD is a convenient and effective approach to analyze the Lagrangian behavior of blood in a heart assist device.
Publisher
ASME International
Subject
Mechanical Engineering
Reference45 articles.
1. Noon, G. P., Morley, D. L., Irwin, S., Abdelsayed, S. V., Benkowski, R. J., and Lynch, B. E., 2001, “Clinical experience with the MicroMed DeBakey ventricular assist device.” Ann. Thorac. Surg., 71(3 Suppl), 133–8. 2. Tamez, D., Conger, J. L., Jacobs, G., Gregoric, I., Inman, R. W., Radovancevic, B. R., Moore, S. M., Eya, K., Eichstaedt, H., Jarvik, R., and Frazier, O. H., 2000, “In vivo testing of the totally implantable Jarvik 2000 heart system.” ASAIO J., 46(2), 168168. 3. Throckmorton, A. L., Allaire, P. E., Gutgesell, H. G., Matherne, G. P., Olsen, D. B., Wood, H. G., Allaire, J. H., and Patel, S. M., 2002, “Pediatric Circulatory Support Systems.” ASAIO J., 48, 216–221. 4. Muller, J., Weng, Y., Goettel, P., Nuesser, P., Kilic, A., Arndt, A., Merkel, J., and Hetzer, R., “The First Implantations in Patients of the InCor I Axial Flow Pump with Magnetic Bearings.” 10th Congress of the International Society for Rotary Blood Pumps. Osaka, Japan. 13 September 2002. 5. Leverett, L. B., Hellums, J. D., Alfrey, C. P., et al. 1972, “Red blood cell damage by shear stress.” Biophys. J., 12, 257–73.
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