Abstract
Objective We aimed to evaluate the impact of interaction between <i>APOE</i> ε4 carrier status and body composition measurements on intra- and inter-regional functional connectivity (FC) in mild cognitive impairment (MCI) patients with Aβ deposition.Methods MCI patients with and without <i>APOE</i> ε4 allele (carrier, n=86; non-carrier, n=95) underwent neuropsychological battery, resting-state functional magnetic resonance imaging scans, positron emission tomography scans with [<sup>18</sup>F]flutemetamol, and bioelectrical impedance analysis for measuring body composition. We employed a priori defined regions of interest to investigate the intra- and inter-network FC profiles of default mode network (DMN), central executive network (CEN), and salience network.Results There was a significant interaction of <i>APOE</i> ε4 carrier status with body fat mass index, visceral fat area, and waist-hip circumference ratio for inter-network FC between DMN and CEN, contributing higher fat-related body composition measurements in the <i>APOE</i> ε4 carrier with lower DMN-CEN FC.Conclusion The present results highlight the detrimental effect of <i>APOE</i> ε4 carrier status on the associations between the fat-related body composition measurements and FC in the MCI patients with Aβ accumulation.
Funder
National Research Foundation of Korea
Ministry of Education
Publisher
Korean Neuropsychiatric Association
Subject
Biological Psychiatry,Psychiatry and Mental health
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献