Hepatotoxicity induced by metallic nanoparticles at the cellular level: A review

Author:

Waris Ammara,Sharif SaimaORCID,Naz Shagufta,Manzoor Farkhanda,Jamil Farrukh,Hussain Murid,Choi Yong Jun,Park Young-KwonORCID

Abstract

Nanoparticles are defined as structures of size ranges from 1-100 nm in diameter in at least one direction. Metallic nanoparticles are considered the most potent agents in the modern world because they are used in every field of life, including the biotechnology, medical, textile, and food industries. Owing to their increased application, humans are constantly exposed to these nanoparticles. Their physiochemical characteristics, as their large surface to volume ratio might enhance their toxicity, increased surface area of NPs exhibit increased biological activity i.e reactive oxygen species generation when compared to large particles of the same mass. Consequently, their biosafety is a matter of major concern. The liver is the primary organ for detoxification and the major organ exposed to nanoparticles. After penetrating the body, nanoparticles enter the bloodstream and are internalized by hepatocytes. After penetration, they cause genotoxicity, oxidative stress and histopathology in hepatic tissues.

Publisher

Korean Society of Environmental Engineering

Subject

Environmental Engineering

Cited by 6 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3