Affiliation:
1. Department of Biochemistry , Saveh Branch , Islamic Azad University, Saveh, Iran
2. Department of Biochemistry , School Of Medicine, Saveh Branch , Islamic Azad University, Saveh, Iran
Abstract
Helicobacter pylori is a significant risk factor for chronic gastritis, gastric ulcers, and gastric cancer. The purpose of this article is to investigate the potential impact of fifty herbal compounds derived from Ginger and Parsley plants, known for their antibacterial properties on the Oxygen-insensitive NADPH nitro reductase enzyme of metronidazole-resistant H. pylori. In the present study, the information on the structure of compounds, the H. pylori resistant to metronidazole enzyme, myristicin, and shogaol derivatives were obtained from databases such as ZINC15, RCSB (Protein Data Bank), and PubChem, respectively. Finally, molecular docking was performed with iGemdock2.1 and Molegro Virtual Docker. After molecular docking, four out of the fifty phytocompounds showed the lowest energy and the highest number of interactions with the amino acids at the binding sites. Among these four phytocompounds, the best phytocompound was N-Vanillyloctanamide derived from Ginger. Our molecular docking study suggests that ginger can be introduced as a potential candidate to inhibit the growth of H. pylori.
Reference25 articles.
1. Talebi Bazmin Abadi A, Mohabati Mobarez A, Ajami A, Rafiei A, Taghvaei T. Investigating the antibiotic resistance of Helicobacter pylori isolated from Patients referred to Tubi Sari Medical Complex. J Maz Univ Med. (2009) 19:26-32.
2. Krzyżek P, GoÅciniak G. Morphology of Helicobacter pylori as a result of peptidoglycan and cytoskeleton rearrangements. Prz Gastroenterol. (2018) 13(3):182-95.
3. Bakhshi S, Ghazvini K, Beheshti A, Ahadi M, Sheykhi M. Review of antibiotic resistance of Helicobacter pylori in Iran and the world. Med J Mashhad Univ Med Sci. (2017) 60:648-61.
4. Kao CY, Sheu BS, Wu JJ. Helicobacter pylori infection: An overview of bacterial virulence factors and pathogenesis. Biomed J. (2016) 39(1):14-23.
5. Antimicrobial resistance. Available at: https://www.who.int/health-topics/antimicrobial-resistance. Accessed: 27 November 2022.