7, 12- Dimethylbenz[a]anthracene: A potent and multivariant Chemical carcinogen

Author:

Mirunalini S.,Susmitha R.

Abstract

Cancer is currently the second major cause of mortality globally. It is a collection of disorders categorized as abnormal cell development which can infiltrate and can spread to countless sections of the body. It has been essentially brought about by genetic and environmental sources mainly, countless patients have impacted by ecological factors like polycyclic aromatic hydrocarbons (PAHs). However, many PAHs in the ecosystem are generated from natural factors like direct combustion, petroleum and volcanic activity. Among these, 7,12 dimethylbenz[a]anthracene (DMBA) has been widely recognized for its capability to induce carcinogenesis in animals and humans. The carcinogenic activity of DMBA indicates the impact of well-differentiated tumors and it is recognized for generating DNA-reactive species that increase the oxidative damage in cells through their metabolism. Additionally, the configuration of DNA adducts and oxidative intermediates acquired from DMBA metabolism impairs prominent cellular activities by harming lipid and protein barriers. DNA adduct is made up of highly reactive intermediates. DMBA-induced cancer displayed higher expression of aryl hydrocarbon receptor (AhR), c-Myc, cyclinD1, activation of upstream regulatory mechanisms and frequent detection of NF-κB pathway components. In this study, we emphasized the growth of several cancers and the kinetic impact of DMBA to probable chemical carcinogenic activities.

Publisher

World Researchers Associations

Subject

Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3