Evaluation of some hormones in female having breast cancer before and after radiotherapy

Abstract

Hormones are believed to largely affect cancer risk by controlling the rate of cell differentiation, division and quantity of cancer-vulnerable cells. Higher estrogen levels, progesterone, prolactin and serotonin have been linked to some cancers including breast cancer. The study aims for a relationship between estrogen, progesterone, prolactin and serotonin signaling and breast cancer to shed light on the pivotal role of hormonal imbalance in the development of breast cancer. The study included 50 new female patients with breast cancer, they do not have diseases related to hormones. Patients were followed up and blood samples were taken for the same group of patients when treated with radiation at the fifth and fifteenth doses (patients, R5, R15) with 50 samples of apparently healthy females as comparison group (control), The ages of the patients and healthy people ranged between 25-70 years. Estrogen, progesterone, prolactin and serotonin levels were tested and the results showed a significant increase in the concentration of estrogen at the probability level P˂0.0001 for the three groups (patients, R5, R15) 596.8±107.6 pg/mL, 561.8±103.1 pg/mL, 466.9±80.43 pg/mL respectively compared to the control group of healthy women 178.3±69.74 pg/mL. The results indicated a significant increase in the concentrations of progesterone, prolactin and serotonin at the probability level P˂0.0001 for the three groups (patients, R5, R15) compared to the control group of healthy women and a significant decrease in the concentration of the hormone estrogen, progesterone, prolactin and serotonin at the probability level P˂0.0001 for the group of women treated at the R-15 dose compared to the group of women treated at the dose R-5.