Micro-RNAs and lung cancer: A focus on signaling pathways and therapeutics
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Published:2023-09-15
Issue:10
Volume:18
Page:241-248
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ISSN:0973-6263
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Container-title:Research Journal of Biotechnology
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language:
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Short-container-title:Res. J. Biotech.
Author:
Banerjee Sohom,Koilerian Sharanya,Mandal Abul Kalam Azad
Abstract
Micro-RNAs are short sequences of single-stranded RNA that do not code for proteins but play a crucial role in modulating gene expression in the cell. Micro-RNAs can downregulate the expression of genes and can modify different pathways that are important for proper functioning of the cells. Micro-RNAs are effective as potential biomarkers and therapeutic targets against various diseases including lung cancer. In this review, we take a look at the different micro-RNAs expressed in lung cancer and their targets in various signaling pathways like Wnt, RAS/RAF, PI3K/Akt pathway etc. We also evaluate the current status of micro-RNA - based therapeutics against Small Cell Lung Cancer and Non-Small Cell Lung Cancer, both in the context of pre-clinical studies as well as clinical studies conducted on humans to date.
Publisher
World Researchers Associations
Subject
Applied Microbiology and Biotechnology,Bioengineering,Biotechnology