Synthesis and surface modification of biocompatible mesoporous silica nanoparticles (MSNs) and its biomedical applications: a review

Abstract

This review gives a broad introduction to nanotechnology, mesoporous silica nanoparticles (MSNs) and synthesis techniques, along with their applications. Recent advances in morphological control and surface functionalization of MSNs have improved their biocompatibility and a strong emphasis on the physicochemical characteristics of MSNs, resulting in a step forward in traditional intervention techniques. This review highlights recent improvements in silica-assisted drug delivery systems including MSN-based sustained drug delivery systems and MSN-based controlled, targeted drug delivery systems. Silica nanoparticles can be used to blend different materials, mix different functions and be a cornerstone for a multifunctional nanomedicine podium for multimodal imaging and diagnostics therapy.