Cognitive Function in Type 2 Diabetes Mellitus Patients Taking Metformin and Metformin-Sulfonylurea
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Published:2022-11-30
Issue:4
Volume:17
Page:270
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ISSN:2460-0601
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Container-title:Kesmas: Jurnal Kesehatan Masyarakat Nasional
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language:
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Short-container-title:Kesmas: Jurnal Kesehatan Masyarakat Nasional
Author:
Rachman Abu,Sauriasari Rani,Syafhan Nadia Farhanah,Prawiroharjo Pukovisa,Risni Hindun Wilda
Abstract
The most prescribed antidiabetic drugs in Indonesian primary health care are metformin or a combination of metformin and sulfonylurea. Studies on metformin have shown various impacts on cognitive decline in patients with type 2 diabetes mellitus, whereas sulfonylurea has been shown to reduce this impact. This study aimed to compare the impacts of metformin and metformin-sulfonylurea on cognitive function and determine what factors affected it. This cross-sectional study was conducted at Pasar Minggu Primary Health Care involving 142 type 2 diabetes mellitus patients taking metformin or metformin-sulfonylurea for > 6 months and aged > 36 years. Cognitive function was assessed using the validated Montreal Cognitive Assessment Indonesian version. The effects of metformin and metformin-sulfonylurea on cognitive decline showed no significant difference, even after controlling for covariates (aOR = 1.096; 95% CI = 0.523–2.297; p-value = 0.808). Multivariate analysis showed age (OR = 4.131; 95% CI = 1.271–13.428; p-value = 0.018) and education (OR = 2.746; 95% CI = 1.196–6.305; p-value = 0.017) affected cognitive function. Since a lower education and older age are likely to cause cognitive decline, health professionals are encouraged to work with public health experts to address these risk factors for cognitive function.
Publisher
Kesmas: Jurnal Kesehatan Masyarakat Nasional
Subject
Public Health, Environmental and Occupational Health,Health Policy,Epidemiology