Yetişkin Bir Hastada Glioblastoma Multiforme’nin Spinal Kord Tutulumu: Bir Olgu Sunumu

Abstract

Glioblastoma Multiforme is a primary malignant neoplasm of the central nervous system which has aggressive progression and mostly seen in adults. Literature accepts the treatment for Glioblastoma Multiforme as combined process of surgical, concurrent chemo-radiotherapy, adjuvant chemotherapy. Glioblastoma Multiforme can spread in a variety of ways. Intraparenchymal spread by using white matter tracts is the most known way of spreading. Dissemination of Glioblastoma Multiforme through cerebrospinal fluid can happen, causing drop metastases, leptomeningeal spread and spinal metastasis. Treatment guideline for leptomeningeal spread in patients with Glioblastoma Multiforme has never been prepared. However, complete surgical removal of the tumor is the accepted treatment of Glioblastoma Multiforme. Surgical treatment is an important option in patients with spinal cord compression with solitary metastases. However, palliative radiotherapy and chemotherapy can be used in the treatment of patients with extensive spinal canal involvement and spinal cord compression. We present a case in which we applied radiotherapy because of spinal cord metastasis that developed after Glioblastoma Multiforme treatment in an adult patient. Through these observations, we analyze therapeutic options of Glioblastoma Multiforme with spinal cord involvement.