Cannabis sativa-mediated synthesis of gold nanoparticles and their biomedical properties

Abstract

Nanotechnology describes precision manufacturing of materials at the nano scale. Nanotechnology has a vast range of applications, such as medicines, electronics, biomaterials and energy production. The present research work is a green eco-friendly approach to the production of gold nanoparticles (Au-NPs) by using the plant extract of Cannabis sativa. The appearance of a ruby-red color from a greenish color is the primary indication of the formation of Au-NPs. C. sativa contains some active compounds that were found to be responsible for the reduction of gold and converting it into a bioactive metal. The synthesized Au-NPs were characterized by ultraviolet–visible spectroscopy, high-resolution scanning electron microscopy and Fourier transform infrared spectroscopy. In vitro antimicrobial, cytotoxicity, biocompatibility and enzyme inhibition assays were performed. Notable antimicrobial activities are reported. Bioinspired Au-NPs were found effective against bacterial and fungal strains. A 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was performed to check the leishmanicidal activity against amastigotes (IC50: 171·00 ± 2·28 μg/ml) of Leishmania tropica. Brine shrimp lethality was also shown by the bioinspired Au-NPs. Furthermore, substantial protein kinase inhibition was noted.