A special performance of magnetic nanocatalysts in biomedicine

Abstract

Magnetic nanoparticles (MNPs) are the main source of synthesis and design of magnetic nanocatalysts, which are obtained from iron salts through the chemical coprecipitation method. The main goal of this research is to investigate the absorption, release and antibacterial properties of magnetic nanocatalysts with silica coating and silica/amine linkers. The structure of the obtained nanocatalyst can be detected through scanning electron microscopy, transmission electron miroscopy, energy-dispersive X-ray spectroscopy and infrared spectroscopy. There is a reaction between ampicillin (10 μl, 25 μg/ml) and Fe3O4@SiO2 and Fe3O4@SiO2/NH2 magnetic nanocatalysts (200 mg, 2 mol%) at 25°C and in double-distilled water. In this way, the amount of absorbed ampicillin on the MNPs@silica/amine structure in covalent form is higher than that on the MNPs@silica structure in non-covalent bonding form – namely, 85 to 65%. The rate of release in non-covalent form is above 90%, whereas in covalent form, it is less than 80%. Additionally, the bactericidal activity of nanocatalysts tested separately at a temperature of 37°C for the non-covalent type is 80% compared with that of the covalent type, which is 70%. The overall result was that the percentage efficiency of the absorption/release reaction in the non-covalent bonding state was 10% more than that for the non-covalent bonding state.