Multifunctional di-N-oxide surfactants in fabrication of lipid nanoparticles

Author:

Wiercigroch Katarzyna1,Lewińska Agnieszka2,Wilk Kazimiera A.3

Affiliation:

1. Doctorate student, Faculty of Chemistry, Organic and Pharmaceutical Technology Group, Wrocław University of Technology, Wrocław, Poland

2. Doctorate student, Faculty of Chemistry, University of Wrocław, Wrocław, Poland

3. Full professor, Faculty of Chemistry, Organic and Pharmaceutical Technology Group, Wrocław University of Technology, Wrocław, Poland

Abstract

A homologous series of dicephalic surfactants, 1,1-bis{[3-(N,N-dimethylamino)ethyl]amido}alkane-di-N-oxides (CnMEDA), is reported, and their applicability for stabilization of the lipid nanoparticles (solid lipid nanoparticles (SLNs) or nanostructured lipid carriers (NLCs)) is discussed and compared with that of their counterparts, single-head–single-tail 2-alkanoylamino)ethyldimethylamines (CnEDA). For the SLN formation, solid cetyl palmitate (Crodamol CP-PA-(SG) is applied as the solid lipid, and in the case of NLCs, cetyl palmitate and triglycerides of caprylic/capric are applied as the liquid lipid. Structural parameters of the resulting nanoparticles are characterized by dynamic light scattering, transmission electron microscopy and scanning electron microscopy and thermal behavior by differential scanning calorimetry (DSC). The studied nanoparticles stabilized with dicephalic CnMEDA had a mean diameter of about 145 nm, whereas the particle size of those stabilized with CnEDA is around 160 nm. Zeta potential measurements demonstrated a negative charge of all obtained SLNs and NLCs, and their values are between −7 and −20 mV. These characteristics remained unchanged for samples stabilized with CnMEDA for least 3 months, suggesting good stability. According to the DSC findings, the NLCs stabilized by the tested CnMEDA had lower values for phase transition temperature, melting enthalpy and the recrystallization index than those obtained for the SLNs. The obtained findings suggest that less ordered crystalline structure is conferred by the inclusion of the liquid lipid. Moreover, the SLNs and NLCs stabilized by dicephalic surfactants constitute more stable products than those stabilized by their linear counterparts.

Publisher

Thomas Telford Ltd.

Subject

Materials Chemistry,Surfaces, Coatings and Films,Process Chemistry and Technology

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