An interaction between growth hormone/insulin-like growth factor-1 and vitamin D in children with short stature

Author:

Bolshova O.V.1ORCID,Sprynchuk N.A.1ORCID,Kvacheniuk D.A.1ORCID,Muz N.M.1ORCID,Ryznychuk M.O.2ORCID,Lukashuk I.V.1ORCID,Malinovska T.M.1ORCID,Samson O.Y.1ORCID,Vyshnevska O.A.1ORCID,Pakhomova V.H.1ORCID

Affiliation:

1. SI “V.P. Komisarenko Institute of Endocrinology and Metabolism of the NAMS of Ukraine”, Kyiv, Ukraine

2. Bukovinian State Medical University, Chernivtsi, Ukraine

Abstract

There are disorders in the growth hormone (GH)/growth factors system in a significant part of patients with short stature; first of all, this concerns such diseases as growth hormone deficiency, where there is a sharp decrease in GH, insulin-like growth factor-1 (IGF-1). The association between vitamin D and GH/growth factor system remains unclear. It was found that vitamin D is able to increase IGF-1 level in healthy individuals. Linear growth is accelerated after treatment of vitamin D deficiency in children, which may indicate the linking role of vitamin D between the proliferative cells of the growth plate cartilage and GH/growth factor system.Research objective: to determine 25-hydroxyvitamin D level in blood plasma in children with short stature, depending on the state of GH/IGF-1 system.Materials and methods. Study included 101 children with short stature: 33 children with partial somatotropic insufficiency (group 1); 44 children with complete somatotropic insufficiency (group 2); 24 children with syndrome of biologically inactive GH (group 3). Patients in groups 1 and 2 had a confirmed GH deficiency and a decrease or sharp decrease in of IGF-1 level; patients in group 3 had a normal stimulated release of GH against the background of a reduced IGF-1 level. GH, IGF-1, 25-hydroxyvitamin D, thyroid-stimulating hormone, and free thyroxine were determined in all children.Results. The average level of vitamin D in three groups corresponded to the vitamin deficiency according to international standards and was 52.24 ± 5.99 nmol/l in patients with partial somatotropic insufficiency, 67.6 ± 5.35 nmol/l in patients with complete somatotropic insufficiency and 58, ± 7.91 nmol/l in patients with syndrome of biologically inactive GH. A direct correlation was found between vitamin D and background GH level, stimulated GH level in children with both partial and complete somatotropic insufficiency. A direct correlation between vitamin D and IGF-1 level in this group of patients was also detected.Conclusions. It is advisable to determine the serum 25(OH)D in all children with short stature. Vitamin D levels should be taken into account in insulin/clonidine diagnostic tests in order to obtain a realistic indication of stimulated GH and IGF-1 levels.

Publisher

Publishing Office TRILIST

Subject

Obstetrics and Gynecology,Reproductive Medicine,Endocrinology, Diabetes and Metabolism

Reference34 articles.

1. The continuum of growth hormone-IGF-I axis defects causing short stature: diagnostic and therapeutic challenges: Continuum of GH-IGF-I defects in short stature;Savage;Clinical Endocrinology,2009-12-29

2. Nestlé Nutrition Institute Workshop Series;Rosenfeld;Importance of Growth for Health and Development: 65th Nestlé Nutrition Institute Workshop, Pediatric Program, Kuala Lumpur, March 2009,2010-01-01

3. Vitamin D and growth hormone regulate growth hormone/insulin-like growth factor (GH–IGF) axis gene expression in human fetal epiphyseal chondrocytes;Fernández-Cancio;Growth Hormone & IGF Research,2009-06-01

4. Endocrine Control of Growth: AMERICAN JOURNAL OF MEDICAL GENETICS PART C (SEMINARS IN MEDICAL GENETICS);MURRAY;American Journal of Medical Genetics Part C: Seminars in Medical Genetics,2013-04-23

5. Fisiologia do eixo GH-sistema IGF;Martinelli Jr;Arquivos Brasileiros de Endocrinologia & Metabologia,2008-07-01

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3