Intraperitoneal Ropivacaine for Effective Pain Relief after Laparoscopic Appendectomy: A Prospective, Randomized, Double-blind, Placebo-controlled Study

Author:

Kang H1,Kim B-G2

Affiliation:

1. Department of Anaesthesiology and Pain Medicine, College of Medicine, Chung-Ang University, Seoul, Republic of Korea

2. Department of Surgery, College of Medicine, Chung-Ang University, Seoul, Republic of Korea

Abstract

This prospective, randomized, double-blind, placebo-controlled study evaluated the effectiveness of intraperitoneal instillation of ropivacaine in the relief of pain in patients undergoing laparoscopic appendectomy. Patients in group C (placebo control group; n = 33) received normal saline and those in group I (instillation group; n = 30) received an instillation of 2 mg/kg ropivacaine at the initiation of the pneumoperitoneum. Visual analogue scale pain scores, fentanyl consumption and the frequency at which patients pushed the button (FPB) of a patient-controlled analgesia system during the post-operative period were significantly lower in group I compared with group C, and decreased gradually with time in both groups. The total amount of fentanyl consumed and the total FPB were significantly lower in group I compared with group C. Thus, intraperitoneal ropivacaine instillation reduced pain during the post-operative period after laparoscopic appendectomy. In addition, this drug was easy to administer and had no adverse effects at the dose used.

Publisher

SAGE Publications

Subject

Biochemistry (medical),Cell Biology,Biochemistry,General Medicine

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