A Therapy-Resistant Chronic Leg Ulcer Treated Successfully with Topical Basic Fibroblast Growth Factor-Reference-Cited by-同舟云学术

A Therapy-Resistant Chronic Leg Ulcer Treated Successfully with Topical Basic Fibroblast Growth Factor

Published:2003-04 Issue:2 Volume:31 Page:149-151
ISSN:0300-0605
Container-title:Journal of International Medical Research
language:en
Short-container-title:J Int Med Res

Author:

Kurokawa I¹,Hayami J¹,Kita Y²

Affiliation:

1. Department of Dermatology, Hyogo Prefectural Tsukaguchi Hospital, Hyogo, Japan

2. Department of Internal Medicine, Hyogo Prefectural Tsukaguchi Hospital, Hyogo, Japan

Abstract

We report a patient with rheumatoid arthritis who had a chronic leg ulcer with long-standing resistance to therapy. Topical basic fibroblast growth factor (bFGF) at a dose of 30 μg/day for 3 months was clinically effective in reducing the ulcer area by promoting angiogenesis, re-epithelization, granulation and scar formation. bFGF may be an effective treatment for therapy-resistant leg ulcers.

Publisher

SAGE Publications

Subject

Biochemistry, medical,Cell Biology,Biochemistry,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/147323000303100212

Reference8 articles.

1. Localisation of a fibroblast growth factor and its effect alone and with hydrocortisone on 3T3 cell growth

2. Quantitation of rheumatoid factor by laser nephelometry

3. Cutaneous Wound Healing

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